Results 211 to 220 of about 11,428 (247)

[Absorption of zedoary oil in rat intestine using in situ single pass perfusion model].

Yao xue xue bao = Acta pharmaceutica Sinica, 2005
To study the absorption of zedoary oil in intestine of rat.In situ single pass perfusion model was used and the concentrations of three components in perfusate were determined by HPLC in combination with diode array detection.The P(app) s of curcumol, curdione and germacrone were all low and had no significant difference (P > 0.05) at zedoary oil ...
Jian, You, Qing-po, Li, Ying-wei, Yu, Fu-de, Cui   +3 more
openaire   +1 more source

[Overall intestinal permeability of multiple components in lotus leaf by in situ single pass intestinal perfusion models].

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2018
To investigate the overall intestinal permeability of multiple components in lotus leaves and make clear the interaction in composition absorption process. Rat single-pass intestinal perfusion technique was used, and the results showed that the Peff values of nuciferine, demethylanuciferine, rutin, quercetin, kaempferol from lotus leaf were greater ...
Xiu-Wen, Yin, Cheng-Bo, Hou, Jiang-Peng, Chen, Meng, Pan, Xue-Lian, Li, Zi-Yu, Wang, Ling, Dong   +6 more
openaire   +1 more source

Segmental-dependent permeability throughout the small intestine following oral drug administration: Single-pass vs. Doluisio approach to in-situ rat perfusion

International Journal of Pharmaceutics, 2016
Intestinal drug permeability is position dependent and pertains to a specific point along the intestinal membrane, and the resulted segmental-dependent permeability phenomenon has been recognized as a critical factor in the overall absorption of drug following oral administration. The aim of this research was to compare segmental-dependent permeability
Isabel, Lozoya-Agullo, Moran, Zur, Avital, Beig, Noa, Fine, Yael, Cohen, Marta, González-Álvarez, Matilde, Merino-Sanjuán, Isabel, González-Álvarez, Marival, Bermejo, Arik, Dahan   +9 more
openaire   +2 more sources

[Studies on intestinal absorption of alkaloids in Coptis chinensis by in situ single-pass perfused rat intestinal model].

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2012
To study the absorption characteristics of alkaloids in Coptis chinensis in rat intestinal.In situ single-pass perfused rat intestinal model was used and the concentrations of berberine and palmatine were determined by HPLC, the drug absorption rate constant (K(a)) and apparent absorption coefficient (P(app)) were tested to evaluate their absorption ...
Ying, Chen, Qing, Yang, Lijuan, Zou, Yujie, Li, Yiwei, Wang, Xiaogang, Weng, Wei, Men, Xiaoxin, Zhu   +7 more
openaire   +1 more source

Liquiritin enhancing intestinal absorption of paeoniflorin in in situ single-pass intestinal perfusion and in vitro Caco-2 cell monolayer absorption models

, 2021
Rui He, Si Wang, Qing Liu, Kai-li Xie, Yong-song Xu, JinLi Shi, Zhimin Wang, Muxin Gong   +7 more
semanticscholar   +1 more source

[In situ rats single pass perfusion intestinal absorption of the effectivein components in Radix Angelicae Pubescentis].

Yao xue xue bao = Acta pharmaceutica Sinica, 2009
In order to study the intestinal absorption behaviors of three active constituents, columbianetin acetate, osthole and columbianadin in Radix Angelicae Pubescentis extracts, in situ rat single pass intestine perfusion (SPIP) was carried out by the perfusion solution of the extract I containing less than 10% total coumarins. The absorption of extract II
Ya-Na, Wu, Li-Biao, Luan
openaire   +1 more source

[Intestinal absorption of different combinations of active compounds from Gegenqinlian decoction by rat single pass intestinal perfusion in situ].

Yao xue xue bao = Acta pharmaceutica Sinica, 2013
The aim is to study the intestinal absorption of different combinations of active compounds out of Gegenqinlian decoction. Rat single pass intestinal perfusion model with jugular vein cannulated was used. Samples were obtained continuously from the outlet perfusate and the mesenteric vein.
Rui, An, Hua, Zhang, Yi-Zhu, Zhang, Ran-Chi, Xu, Xin-Hong, Wang   +4 more
openaire   +1 more source

In-situ intestinal rat perfusions for human Fabs prediction and BCS permeability class determination: Investigation of the single-pass vs. the Doluisio experimental approaches

International Journal of Pharmaceutics, 2015
Intestinal drug permeability has been recognized as a critical determinant of the fraction dose absorbed, with direct influence on bioavailability, bioequivalence and biowaiver. The purpose of this research was to compare intestinal permeability values obtained by two different intestinal rat perfusion methods: the single-pass intestinal perfusion ...
Isabel, Lozoya-Agullo, Moran, Zur, Omri, Wolk, Avital, Beig, Isabel, González-Álvarez, Marta, González-Álvarez, Matilde, Merino-Sanjuán, Marival, Bermejo, Arik, Dahan   +8 more
openaire   +2 more sources

[Intestinal absorption of the effective components of Schisandra chinensis Baill by rats single-pass perfusion in situ].

Yao xue xue bao = Acta pharmaceutica Sinica, 2012
The aim of the study is to investigate rat intestinal absorption behavior of three main active components, schisandrol A, schisandrin A and schisandrin B in Schisandra chinensis Baill extracts in intestine of rats. With phenol red as the indicator, in situ single pass intestinal perfusion (SPIP) model was used and the concentrations of three main ...
Xin-Min, Chen, Jun-Song, Li, Wen, Li, Lei, Han, Xun-Hong, Liu, Liu-Qing, Di, Bao-Chang, Cai   +6 more
openaire   +1 more source

In Situ Single Pass Perfused Rat Intestinal Model

2013
Maria Markowska, L. Mark Kao
openaire   +1 more source