Results 31 to 40 of about 218,898 (267)

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Inversion of In-situ stress field in near-fault coal mining area by coupling numerical simulation with deep learning

Geomatics, Natural Hazards & Risk
Understanding the in-situ stress distribution is crucial for coal mine production. In mining area 105 of Yuandian No. 1 Coal Mine, in-situ stress measurements were carried out using the stress relief method.
Rongqin Deng, Yuan Zhang, Dong Wu, Jiakun Lv, Yanan Jing, Zheng Zhen, Peng Shi   +6 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

3D In Situ Stress Estimation by Inverse Analysis of Tectonic Strains

Applied Sciences, 2021
The determination of a 3D engineering-scale in situ stress field is essential in underground rock mechanics and engineering. The inverse analysis method is a useful technique to determine the in situ stress around the zone of interest.
Mingwei Guo, Shunde Yin, Chunguang Li, Shuilin Wang   +3 more
doaj   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

The Current Stress State and Seismic Hazard in the Kunlun Pass Region Following the Ms 8.1 Earthquake in 2001

Applied Sciences
The Kusaihu and Xidatan faults in the western part of the East Kunlun active fault present a miter compound relationship. The Quaternary activity of these two faults is vigorous and closely associated with potent and large earthquakes.
Jun Qiu, La Ta, Jiading Xu, Leilei Li, Lianshan Wang   +4 more
doaj   +1 more source

In situ stress state from walkaround VSP anisotropy in the Kumano basin southeast of the Kii Peninsula, Japan

Geochemistry, Geophysics, Geosystems, 2011
To reveal the stress state within the Kumano basin, which overlies the Nankai accretionary prism, we estimated seismic anisotropy from walkaround vertical seismic profiling (VSP) data recorded at Site C0009 during Integrated Ocean Drilling Program (IODP)
Takeshi Tsuji, Ryota Hino, Yoshinori Sanada, Kiyohiko Yamamoto, Jin‐Oh Park, Tetsuo No, Eiichiro Araki, Nathan Bangs, Roland von Huene, Gregory Moore, Masataka Kinoshita   +10 more
doaj   +1 more source

In-situ Stress Analysis and Rockburst Risk Assessment of Liupanshan Tunnel of Bailong River Water Diversion Project [PDF]

长江科学院院报
[Objective] Taking the deeply buried Liupanshan tunnel of the Bailong River Diversion Project as the research background, this study aims to systematically investigate the distribution characteristics of the in-situ stress field along the tunnel ...
DONG Zhi-hong, JIANG Jian, ZHANG Xin-hui, ZHOU Chao, ZUO Qing-jun
doaj   +1 more source