Results 51 to 60 of about 115,032,361 (201)

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

The Current Stress State and Seismic Hazard in the Kunlun Pass Region Following the Ms 8.1 Earthquake in 2001

Applied Sciences
The Kusaihu and Xidatan faults in the western part of the East Kunlun active fault present a miter compound relationship. The Quaternary activity of these two faults is vigorous and closely associated with potent and large earthquakes.
Jun Qiu, La Ta, Jiading Xu, Leilei Li, Lianshan Wang   +4 more
doaj   +1 more source

In situ stress distribution law of fault zone in tunnel site area based on the inversion method with optimized fitting conditions

Frontiers in Earth Science, 2023
Tunnel construction in high geo-stress strata faces the risk of extreme natural disasters such as large squeezing deformation and rockburst. Therefore, it is of great significance to adopt a high-precision inversion method to investigate the distribution
Tiansheng Li, Tiansheng Li, Ziquan Chen, Zihan Zhou, Yeming Bao   +4 more
doaj   +1 more source

Predictive and prognostic biomarkers of Bacillus Calmette‐Guérin therapy failure in bladder cancer patients: A systematic review

Molecular Oncology, EarlyView.
High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira, Ana Teixeira‐Marques, Rui Freitas, João A Carvalho, Sara Monteiro‐Reis, Giorgio I. Russo, Rui Henrique, Carmen Jerónimo   +7 more
wiley   +1 more source

Lipopolysaccharide, high glucose and saturated fatty acids induce endoplasmic reticulum stress in cultured primary human adipocytes : salicylate alleviates this stress [PDF]

, 2010
Recent findings indicate that endoplasmic reticulum (ER) stress is significantly increased in adipose tissue of obese human subjects and is critical to the initiation and integration of pathways of inflammation and insulin action.
Saif Alhusaini, Harte, A., McGee, K., Gyanendra Tripathi, Kumar, Sudhesh, Tripathi, Gyanendra, Sudhesh Kumar, Alhusaini, S., McTernan, P. G., Harte, A. L., McTernan, P., Bruno Schisano, Philip McTernan, Schisano, B., McGee, K. C., Kumar, S., Alison Harte, Tripathi, G., Kirsty McGee   +18 more
core   +1 more source

Influence of Stress Level on the Determination of In Situ Stress by DRA Method

Buildings
Obtaining reliable in situ stress field data is the precondition of the design and excavation of underground engineering. The deformation rate analysis (DRA) method based on the rock deformation memory effect is an effective method for testing in situ ...
Yuxin Ban, Qiang Xie, Jiahui Tang, Jun Duan, Xiang Fu, Xiaoqiang Xue   +5 more
doaj   +1 more source

In situ stress state from walkaround VSP anisotropy in the Kumano basin southeast of the Kii Peninsula, Japan

Geochemistry, Geophysics, Geosystems, 2011
To reveal the stress state within the Kumano basin, which overlies the Nankai accretionary prism, we estimated seismic anisotropy from walkaround vertical seismic profiling (VSP) data recorded at Site C0009 during Integrated Ocean Drilling Program (IODP)
Takeshi Tsuji, Ryota Hino, Yoshinori Sanada, Kiyohiko Yamamoto, Jin‐Oh Park, Tetsuo No, Eiichiro Araki, Nathan Bangs, Roland von Huene, Gregory Moore, Masataka Kinoshita   +10 more
doaj   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Burgemeester van Suchtelenstraat Ex-Situ Archeologierapport 5

, 2022
Op 19 februari 2019 heeft Ex-Situ Archeologie een proefsleuvenonderzoek uitgevoerd op het perceel Burgermeester van Suchtelenstraat in de gemeente Beuningen.
Ex-Situ arch. advies en projectbureau
core   +1 more source

A Fiber Bragg Grating Borehole Deformation Sensor for Stress Measurement in Coal Mine Rock

Sensors, 2020
A borehole deformation sensor for long-term stress monitoring in coal mine rock based on optical fiber Bragg gratings (FBGs) is presented. The sensor converts borehole deformation into optical fiber strain by using four rings. For each ring, two FBGs are
Wusheng Zhao, Kun Zhong, Weizhong Chen
doaj   +1 more source