Results 41 to 50 of about 115,032,361 (201)

A novel model for calculating in situ stress within deep coal seams considering microstructural characteristics and its application

Meitian dizhi yu kantan
Objective Research on in situ stress serves as a bridge between geological and engineering analyses. Accurate insights into in situ stress regimes are crucial for ensuring engineering efficiency and development benefits. However, microstructures are well
Haifeng ZHAO, Hongwei SHI, Fei XIE, Chengwang WANG, Zongfei WANG, Gaojie CHEN   +5 more
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

Inversion of In-situ stress field in near-fault coal mining area by coupling numerical simulation with deep learning

Geomatics, Natural Hazards & Risk
Understanding the in-situ stress distribution is crucial for coal mine production. In mining area 105 of Yuandian No. 1 Coal Mine, in-situ stress measurements were carried out using the stress relief method.
Rongqin Deng, Yuan Zhang, Dong Wu, Jiakun Lv, Yanan Jing, Zheng Zhen, Peng Shi   +6 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Advances in martensitic transformations in Cu-based shape memory alloys achieved by in situ neutron and synchrotron X-ray diffraction methods [PDF]

, 2012
This article deals with the application of several X-ray and neutron diffraction methods to investigate the mechanics of a stress induced martensitic transformation in Cu-based shape memory alloy polycrystals. It puts experimental results obtained by two
Sophie Berveiller, Benoit Malard, Etienne Patoor, Petr Sittner, Berveiller, Sophie, Patoor, Etienne, Malard, Benoît, Sittner, Petr   +7 more
core   +1 more source

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

Molecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic, Maria Concetta Vitale, Rita Siino, Emilia Di Giovanni, Carla Ferrante Bannera, Enrico Di Marco, Andrea Gottardo, Tancredi Didier Bazan Russo, Nadia Barraco, Alessandro Perez, Valerio Gristina, Antonio Galvano, Giuseppe Badalamenti, Antonio Russo, Viviana Bazan, Lorena Incorvaia   +15 more
wiley   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Minimum stress and pore fluid pressure in sedimentary basins [PDF]

, 2001
Leak-off pressures (LOPs) recorded during leak-off tests (LOTs) conducted down boreholes are often used to estimate the magnitude of the minimum stress (usually assumed to be horizontal – S(_h)) in the subsurface.
White, Adrian James
core  

3D In Situ Stress Estimation by Inverse Analysis of Tectonic Strains

Applied Sciences, 2021
The determination of a 3D engineering-scale in situ stress field is essential in underground rock mechanics and engineering. The inverse analysis method is a useful technique to determine the in situ stress around the zone of interest.
Mingwei Guo, Shunde Yin, Chunguang Li, Shuilin Wang   +3 more
doaj   +1 more source