Results 51 to 60 of about 568,096 (301)

Dermal Delivery of Niacinamide—In Vivo Studies

Pharmaceutics, 2021
In vivo human studies are considered to be the “gold standard” when investigating (trans)dermal delivery of actives. Previously, we reported the effects of a range of vehicles on the delivery of niacinamide (NIA) using conventional Franz cell studies. In
Yanling Zhang, Chin-Ping Kung, Fotis Iliopoulos, Bruno C. Sil, Jonathan Hadgraft, Majella E. Lane   +5 more
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Analysis of clinical research coordinator (CRC) deviation from assigned responsibilities in Sichuan, China based on empirical investigation

Frontiers in Medicine
ObjectiveExploring the current status and causes of overstepping behavior among clinical research coordinators: providing reference for standardizing CRC responsibilities and safeguarding clinical trial quality and subject safety.MethodsThe research ...
Shuxia Shi, Shuxia Shi, Shuxia Shi, Shuxia Shi, Shangyuan Qin, Qin Yu, Qin Yu, Qin Yu, Qin Yu   +8 more
doaj   +1 more source

Long-Acting Injectable Antipsychotics—A Review on Formulation and In Vitro Dissolution

Pharmaceutics, 2023
Long-acting injectable (LAI) neuroleptics constitute an effective therapeutical alternative for individuals suffering from persistent mental illness.
Magdalena Markowicz-Piasecka, Marcin Kubisiak, Katarzyna Asendrych-Wicik, Michał Kołodziejczyk, Joanna Grzelińska, Małgorzata Fabijańska, Tomasz Pietrzak   +6 more
doaj   +1 more source

Avaliação toxicológica de nanopartículas compostas de dióxido de titânio, superparamagnéticas de óxido de ferro e de poliuretano in vitro, in vivo, ex vivo e in silico [PDF]

, 2015
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde, Programa de Pós-Graduação em Farmácia, Florianópolis, 2015.A nanotecnologia envolve a compreensão e manipulação da matéria em escala nanométrica, em que os ...
Silva, Adny Henrique
core  

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

Dissolution method for delapril and manidipine combination tablets based on an absorption profile of manidipine

Journal of Pharmaceutical Analysis, 2016
The present study describes the development and validation of a dissolution method for delapril (DEL) and manidipine (MAN) combination tablets, using a simulated absorption profile based on in vivo data for MAN.
Vítor Todeschini, Maximiliano S. Sangoi, Gustavo K. Goelzer, Jaison C. Machado, Clésio S. Paim, Bibiana V. Araujo, Nadia M. Volpato   +6 more
doaj   +1 more source

In vitro screening of probiotic lactic acid bacteria and prebiotic glucooligosaccharides to select effective synbiotics [PDF]

, 2010
Probiotics and prebiotics have been demonstrated to positively modulate the intestinal microflora and could promote host health. Although some studies have been performed on combinations of probiotics and prebiotics, constituting synbiotics, results on ...
Julien Grimoud, Durand, Henri, Henri Durand, Monsan, Pierre, Courtin, Céline, Grimoud, Julien, Theodorou, Vassilia, Christine Roques, Pierre Monsan, Françoise Ouarné, Ouarné, Françoise, Céline Courtin, Roques, Christine, Rogues, Christine, Vassilia Theodorou   +14 more
core   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

In vitro -in vivo correlation and biopharmaceutical classification system [PDF]

Chronicles of Young Scientists, 2011
In vitro dissolution has been extensively used as a quality control tool for solid oral dosage forms. In several cases, however, it is not known whether one can predict the in vivo performance of these products from in vitro dissolution data. In an effort to minimize unnecessary human testing, investigations of in vitro–in vivo correlations (IVIVC ...
Tiwari, G., Srivastawa, B., Pandey, S., Tiwari, R., Rai, A.K., Pandey, P., Bhati, L.   +6 more
openaire   +2 more sources