Results 101 to 110 of about 8,658,473 (396)

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

Molecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser, Florian Krumbach, Eyleen Corrales, Geoffroy Andrieux, Christian Preisinger, Franziska Liss, Alexandra Golzmann, Melanie Boerries, Kerstin Becker, Ruth Knüchel, Stefan Garczyk, Bernhard Lüscher   +11 more
wiley   +1 more source

Critical Implications of IVDR for Innovation in Diagnostics: Input From the BioMed Alliance Diagnostics Task Force

HemaSphere, 2022
Isabel Dombrink, Bart R. Lubbers, Loredana Simulescu, Robin Doeswijk, Olga Tkachenko, Elisabeth Dequeker, Alan G. Fraser, Jacques J. M. van Dongen, Christa Cobbaert, Monika Brüggemann, Elizabeth Macintyre   +10 more
doaj   +1 more source

New Horizons in Skin Sensitization Assessment of Complex Mixtures: The Use of New Approach Methodologies Beyond Regulatory Approaches

Toxics
Skin sensitization is a complex biological process induced by a wide range of chemicals, from single molecules to complex mixtures and finished products.
Argel Islas-Robles, Meera Ramani, Jakeb Phillips, Gertrude-Emilia Costin   +3 more
doaj   +1 more source

How to Ease the Pain of Taking a Diagnostic Point of Care Test to the Market: A Framework for Evidence Development

Micromachines, 2020
Bringing a diagnostic point of care test (POCT) to a healthcare market can be a painful experience as it requires the manufacturer to meet considerable technical, financial, managerial, and regulatory challenges.
Sara Graziadio, Amanda Winter, B. Clare Lendrem, Jana Suklan, William S. Jones, Samuel G. Urwin, Rachel A. O’Leary, Rachel Dickinson, Anna Halstead, Kasia Kurowska, Kile Green, Andrew Sims, A. John Simpson, H. Michael Power, A. Joy Allen   +14 more
doaj   +1 more source

Flow-enhanced vascularization and maturation of kidney organoids in vitro

Nature Methods, 2018
Kidney organoids derived from human pluripotent stem cells have glomerular- and tubular-like compartments that are largely avascular and immature in static culture.
Kimberly A Homan, Navin R Gupta, Katharina T. Kroll, David B. Kolesky, Mark A. Skylar-Scott, Tomoya Miyoshi, Donald Mau, M. T. Valerius, Thomas C. Ferrante, Joseph V. Bonventre, Jennifer A. Lewis, Ryuji Morizane   +11 more
semanticscholar   +1 more source

Escape from TGF‐β‐induced senescence promotes aggressive hallmarks in epithelial hepatocellular carcinoma cells

Molecular Oncology, EarlyView.
Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu, Dilara Demirci, Sude Eris, Bengisu Dayanc, Ece Cakiroglu, Merve Basol, Merve Uysal, Gulcin Cakan‐Akdogan, Fang Liu, Mehmet Ozturk, Gökhan Karakülah, Serif Senturk   +11 more
wiley   +1 more source

ShcD adaptor protein drives invasion of triple negative breast cancer cells by aberrant activation of EGFR signaling

Molecular Oncology, EarlyView.
We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau, Hayley S. Smith, Begüm Alural, Claire E. Martin, Laura A. New, Manali Tilak, Sara L. Banerjee, Hannah N. Robeson, Nicolas Bisson, Anne‐Claude Gingras, Jasmin Lalonde, Nina Jones   +11 more
wiley   +1 more source

Reductive modification of genetically encoded 3-nitrotyrosine sites in alpha synuclein expressed in E.coli

Redox Biology, 2019
Tyrosine nitration is a post-translational protein modification relevant to various pathophysiological processes. Chemical nitration procedures have been used to generate and study nitrated proteins, but these methods regularly lead to modifications at ...
Hanne R. Gerding, Christiaan Karreman, Andreas Daiber, Johannes Delp, Daniel Hammler, Martin Mex, Stefan Schildknecht, Marcel Leist   +7 more
doaj   +1 more source

Penyimpanan in Vitro Tanaman Obat Daun Dewa Melalui Pertumbuhan Minimal [PDF]

, 2005
Daun dewa (Gynura Procumbens) is a medicinal crop commonly used to remedy cancer, diabetes, and dermatitis. It has a bright prospect for future used. Plant preservations through tissue culture is done to anticipate an urgent need.
Lestari, E. G. (Endang), Purnamaningsih, R. (Ragapadmi)   +1 more
core  

Blood-Contacting Biomaterials: In Vitro Evaluation of the Hemocompatibility

Frontiers in Bioengineering and Biotechnology, 2018
Hemocompatibility of blood-contacting biomaterials is one of the most important criteria for their successful in vivo applicability. Thus, extensive in vitro analyses according to ISO 10993-4 are required prior to clinical applications.
Marbod Weber, H. Steinle, S. Golombek, L. Hann, C. Schlensak, H. Wendel, M. Avci-Adali   +6 more
semanticscholar   +1 more source