Results 111 to 120 of about 120,681,618 (266)

Integrating SSR Genotyping and Morphological Traits for Reliable Identification of Apple Rootstocks in Kazakhstan

International Journal of Plant Biology
Apple (Malus domestica Borkh.) rootstocks play a key role in modern intensive orchard systems, where their accurate identification is essential for breeding, nursery production, and certification of planting material.
Aigul Madenova, Raigul Abdikarimova, Zhankeldy Aitymbet, Moldir Askarova, Zarina Yussupova, Irina Kovalchuk, Svetlana Dolgikh, Aigerim Seisenova, Dinara Kaldybayeva, Marina Urazaeva, Sagi Soltanbekov, Balnur Kabylbekova   +11 more
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Flowering and vegetative propagation of pyrethrum (Chrysanthemum cinerariaefolium Vis.) in vivo and in vitro [PDF]

, 1976
The influence of climatic conditions was investigated on flowering behaviour of pyrethrum ( Chrysanthemum cinerariaefolium Vis.). At low temperatures high numbers of plants initiated high numbers of flower heads.
Roest, S.
core  

Multi-endpoint toxicological assessment of polystyrene nano- and microparticles in different biological models in vitro

, 2019
Nanoplastics (NP) and microplastics (MP) accumulate in our environment as a consequence of the massive consumption of plastics. Huge knowledge-gaps exist regarding uptake and fate of plastic particles in micro- and nano-dimensions in humans as well as on
Hesler, Michelle, Meier, Florian Matthias Peter, Ellinger, Bernhard, Buerki-Thurnherr, Tina, Aengenheister, Leonie, Straskraba, Susanne, Wick, Peter, Jost, Carsten, Wagner, Sylvia, Büchel, Claudia, Meier, Florian, Drexel, Roland, Kohl, Yvonne, Bürki-Thurnherr, Tina, Briesen, Hagen von, Kohl, Yvonne (author), Drexel R, Aengenheister L, Kohl Y, Meier, Florian (author), Straskraba, Susanne (author), Meier F, Hesler M, Hesler, Michelle (author), Drexel, Roland (author), Büchel C, Wick P, Straskraba S, Ellinger B, Jost, Carsten (author), Büchel, Claudia (author), Jost C, Wagner, Sylvia (author), von Briesen, Hagen (author), Wagner S, Wick, Peter (author), Ellinger, Bernhard (author), von Briesen H, Buerki-Thurnherr T, Aengenheister, Leonie (author), Buerki-Thurnherr, Tina (author)   +40 more
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

In Vitro Organogenesis And Efficient Plant Regeneration From Root Explants Of Passiflora Suberosa L. (passifloraceae)

, 2016
The neotropical genus Passiflora (Passifloraceae) contains over 500 species of plants, including the commercially important passion fruit. Most of the literature on tissue culture of this genus is devoted to passion fruit or closely related species ...

core   +1 more source

Prevalence, Molecular Detection, and In Vitro Elimination of Latent Viruses and Viroids in Pome Fruit Germplasm of Kazakhstan

Viruses
Latent viral and viroid infections represent a major phytosanitary threat to pome fruit production because infected propagation material facilitates the long-term spread of pathogens in orchards. This study investigated the prevalence of viral and viroid
Aigul Madenova, Dinara Kaldybayeva, Timur Turdiyev, Raigul Abdikarimova, Yerkenaz Kaiypzhan, Balnur Kabylbekova, Sagi Soltanbekov, Zhankeldy Aitymbet, Muhammad Azhar Nadeem, Faheem Shehzad Baloch   +9 more
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Macrophages clear out necrotic liver lesions: a new magic trick revealed

eGastroenterology, 2023
Robim M Rodrigues, Joost Boeckmans, Tamara Vanhaecke   +2 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source