Results 101 to 110 of about 120,681,618 (266)

New Horizons in Skin Sensitization Assessment of Complex Mixtures: The Use of New Approach Methodologies Beyond Regulatory Approaches

Toxics
Skin sensitization is a complex biological process induced by a wide range of chemicals, from single molecules to complex mixtures and finished products.
Argel Islas-Robles, Meera Ramani, Jakeb Phillips, Gertrude-Emilia Costin   +3 more
doaj   +1 more source

DNA ligase LigE increases bacterial transformation with damaged extracellular DNA

FEBS Letters, EarlyView.
The DNA ligase LigE from the naturally competent Gram‐negative bacterium Neisseria gonorrhoaea increases transformation with cut extracellular DNA. This process is ATP‐dependent and relies on the catalytic activity of LigE; it also requires that LigE contains an intact periplasmic localisation sequence, indicating that ligE functions in the periplasm ...
Jolyn Pan, Avi Singh, Shrawani Weralupe Gamladdalage, Joanna Hicks, Adele Williamson   +4 more
wiley   +1 more source

In vitro propagation and cryostorage of Syzygium francissi (Myrtaceae) by the encapsulation-dehydration method

, 2004
An efficient procedure for the in vitro propagation and cryogenic conservation of Syzygium francissi was developed. The maximum number of shoots per explant was obtained on a Murashige and Skoog (MS) medium supplemented with 4.5 μM benzyladenine and 0.5 ...
Fraser R. Torpy, Shatnawi, MA, Torpy, FR, Johnson, KA, Krystyna A. Johnson, M. Awad Shatnawi   +5 more
core   +1 more source

PeriTox-M, a Cell-Based Assay for Peripheral Neurotoxicity with Improved Sensitivity to Mitochondrial Inhibitors

Cells
Human cell-based assays for neurotoxicity (NT) and developmental neurotoxicity (DNT) have reached a high level of readiness, but some tests require improvements in the specificity and sensitivity at which mitochondrial toxicants are detected.
Anna-Katharina Holzer, Mira Dürr, Selina Multrus, Laura Dangel, Viktoria Magel, Marcel Leist   +5 more
doaj   +1 more source

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

Ontogeny of in vitro rooting processes in Eucalyptus globulus

, 2004
Calderon, Ximena. Instituto de Biología Vegetal y Biotecnología, Universidad de Talca, Casilla 747, Talca, Chile.In the present work, histological changes observed at the base of Eucalyptus globulus shoots in in vitro culture are described.
De Garcia, E., Montenegro, G., Calderon, X.   +2 more
core  

Hepatotoxicity of Pyrrolizidine Alkaloids

Journal of Pharmacy & Pharmaceutical Sciences, 2015
PURPOSE: This article aimed 1) to review herbal medicine containing pyrrolizidine alkaloids (PA)-induced toxicities of the liver; 2) to encourage the recognition and prevention of common problems encountered when using complementary and alternative ...
Manuela G Neuman, Lawrence Cohen, Mihai Opris, Radu M Nanau, Hyunjin Jeong   +4 more
doaj   +1 more source

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source

Changes in acetylation of lysine 5 on histone H4 in canine oocytes following in vitro maturation

, 2016
Post-translational modifications of histones, such as acetylation, are involved in regulating chromatin remodelling and gene expression. Proper in vitro maturation (IVM) of canine oocytes, for many reasons, is up to now inefficient.
Alves, A. E., Pires-Buttler, E. A. [UNESP], Arnold, D. R., Motheo, T. F. [UNESP], Lopes, F. L. [UNESP], Vicente, W. R.R. [UNESP], Padilha-Nakaghi, L. C. [UNESP], Apparicio, M., AE Alves, DR Arnold, Lopes, F. L., TF Motheo, FL Lopes, M Apparicio, LC Padilha-Nakaghi, Padilha-Nakaghi, L. C., Motheo, T. F., EA Pires-Buttler, WRR Vicente, Vicente, W. R.R., Pires-Buttler, E. A.   +20 more
core   +1 more source

Comparing the paths of Hedgehog release in artificial and natural settings

FEBS Letters, EarlyView.
Hh morphogens require solubilization factors to overcome their tight association with the plasma membrane and signal to distant cells, but the precise functions of these factors are controversial. Here, we use published in vivo observations as the most relevant evidence to test their suggested functions and discuss contradictions and gaps between in ...
Janna Puschmann, Kay Grobe
wiley   +1 more source