Results 101 to 110 of about 5,663,004 (310)
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
Anticandidal in Vitro Test of Crude Ethanol Extract of Pliek U on the Growth of Candida Albicans [PDF]
, 2011 This research was conducted to know the activity of crude ethanol extract of pliek u (E) through in vitro assays. Pliek u obtained from households industry in the Reudep village Aceh Besar, Aceh province.
Masyitha, D. (Dian) +2 more
core
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
Synthetic in vitro transcriptional oscillators [PDF]
, 2011 The construction of synthetic biochemical circuits from simple components illuminates how complex behaviors can arise in chemistry and builds a foundation for future biological technologies.
Kim, Jongmin, Winfree, Erik
core +1 more source
Molecular Oncology, EarlyView.This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns +10 more
wiley +1 more source
Macrophages clear out necrotic liver lesions: a new magic trick revealed
eGastroenterology, 2023 Robim M Rodrigues +2 more
doaj +1 more source
Uji in Vitro Ekstrak Air Dan Etanol Dari Buah Asam Gelugur, Rimpang Lengkuas, Dan Kencur Sebagai Inhibitor Aktivitas Lipase Pankreas [PDF]
, 2010 Asam gelugur fruits of Garcinia often used to reduce body weight. Lengkuas and kencur are traditional herbal that potential for antiobesity because they could reduce the level of phospholipids, triglycerides, and cholesterol.
Darusman, L. K. (Latifah) +2 more
core
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
Studi in Vitro Biobiodegradasi Microsphere Polilaktat [PDF]
, 2006 STUDI IN VITRO BIOBIODEGRADASI MICROSPHERE POLILAKTAT. Biodegradasi polimer microsphere berbasis polilaktat (PLA) telah dilakukan secara in vitro pada lingkungan yang mendekati kondisi dalamtubuhmanusia (pH 7,4 dan suhu 37°C).
Handayani, A. (Ari) +3 more
core
Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma
Molecular Oncology, EarlyView.Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra +6 more
wiley +1 more source