Results 81 to 90 of about 165,330 (303)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Cost of Conservation of Agrobiodiversity [PDF]

The cost of conservation of germplasm stored in gene banks i.e., ex-situ collections has been studied in other parts of the world to estimate direct and indirect contributions by various actors involved in conservation.
Saxena Sanjeev, Sinha Riya, Gosh Shrabani B, Chandak Vikas, Jain Neeru, Gupta, Anil K.   +5 more
core  

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Unveiling the Balkans’ advances: In vitro biotechnology of woody plants in the early 21st century

Frontiers in Plant Science
The Balkan Peninsula is a European biodiversity hotspot, home to 6,500 native vascular plant species, many of which are endemic. The region has diverse range of climates and complex topography, creating conditions that suit many woody ornamental, fruit ...
Valbona Sota, Valbona Sota, Lilyana Nacheva, Dejan Bošnjak, Eleni Abraham, Slađana Jevremović, Branislav Cvjetković, Vladislava Galović, Darko Jevremović, Zvjezdana Marković, Efigjeni Kongjika, Sanja Bogunović, Svjetlana Zeljković, Vlatko Andonovski, Vanja Daničić, Tatjana Vujović   +15 more
doaj   +1 more source

Contingent valuation analysis of rural households’ willingness to pay for frankincense forest conservation [PDF]

Frankincense from Boswellia papyrifera forest (BPF) is a traded non timber forest product (NTFP) used in pharmaceutical, food, cosmetic and chemical industries.
Gebregziabher, Kidanemariam, Muys, Bart, Tilahun, Mesfin, Bauer, Hans, Mathijs, Erik, Vranken, Liesbet, Deckers, Jozef A., Gebrehiwot, Kindeya   +7 more
core   +1 more source

In Vitro techniques for grapevine germplasm conservation. [PDF]

, 2016
Plant genetic resources hold significant phenotypic variation resultant from the presence of allelic diversity, which is maintained by evolutionary processes or by artificial selection.
COMACHIO, V., RITSCHEL, P. S., MAIA, J. D. G., QUECINI, V., SINSKI, I., BOSCO, D. D.   +5 more
core  

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

On the issue of conservation of typhus virus in vitro

Kazan medical journal, 1935
Until now, it was believed that glycerin quickly destroys the typhus virus. The authors showed that destruction does not take place at low temperatures and recommend preserving the typhus virus by placing infected virulent pieces of organs in a test tube with glycerol and preserving it in a freezing apparatus at 12-15 below zero.
I. Laigrеtu, R. Durand
openaire   +1 more source

Efeitos estruturais do cultivo in vitro e aclimatização ex vitro em raiz e folha de espécies de Cattleya Lindl. (Orchidaceae) [PDF]

, 2015
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Agrárias, Programa de Pós-Graduação em Recursos Genéticos Vegetais, Florianópolis, 2015.A propagação in vitro de orquídeas constitui um dos métodos mais conhecidos e ...
Lando, Ana Paula
core  

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source