Results 61 to 70 of about 1,391,044 (313)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Effects of green tea polyphenols, insulin-like growth factor I and glucose on developmental competence of bovine oocytes

Revista Brasileira de Zootecnia, 2012
The present study examined the effects of green tea polyphenols (GTP), insulin-like growth factor-I (IGF-I) and glucose on oocyte in vitro maturation, subsequent embryo development and blastocyst quality in bovine.
Zhengguang Wang, Chunquan Fu, Songdong Yu   +2 more
doaj   +1 more source

In Vitro Porcine Colon Culture

, 2018
Models have been extensively used to investigate disease pathogenesis. Animal models are costly, require extensive logistics for animal care, and samples are not always suitable for different analytical techniques or to answer the research question. In vitro cell culture models are generally focused on recreating a specific characteristic of an organ ...
Costa, Matheus O., Hill, Janet E., Dame, Michael K., Harding, John C.S.   +3 more
openaire   +4 more sources

Effects of strychnopentamine on cells cultured in vitro

Chemico-Biological Interactions, 1991
This paper describes the powerful cytotoxic action exerted by strychnopentamine (SP), a dimeric indole alkaloid extracted from Strychnos usambarensis Gilg, on B16 melanoma cells and on non-cancer human fibroblasts cultured in vitro. SP strongly inhibits cell proliferation and induces cell death at a relatively low concentration (less than 1 microgram ...
Quetin-Leclercq, J., De Pauw-Gillet, Marie-Claire, Angenot, Luc, Bassleer, Roger   +3 more
openaire   +3 more sources

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Acclimatization of Phalaenopsis and Cattleya obtained by micropropagation

Revista Colombiana de Biotecnología, 2010
Título en español: Aclimatización de Phalaenopsis y Cattleya obtenidas por micropropagación ABSTRACT The quality of micropropagated plants relies on the acclimatization stage.
Lucía Primitiva Díaz, Jorge Julio Namur, Sebastián Agustín Bollati, Osvaldo Ernesto Antonio Arce   +3 more
doaj   +2 more sources

Evaluación del efecto del medio MS y la temperatura en el desarrollo de propágulos de Marchantia polymorpha L. (Marchantiaceae) bajo condiciones in vitro y ex vitro

Revista Colombiana de Biotecnología, 2010
En este trabajo de investigación se propagaron, bajo condiciones in vitro, propágulos de Marchantia polymorpha evaluando su desarrollo vegetativo mediante observaciones y registros semanales a cada cultivo por tratamiento en función del tiempo de ...
Jaime Alonso Pedroza-Manrique, Mauricio Caballero Arévalo   +1 more
doaj  

Comparative suitability of two culture media to the in vitro growth of embryos of three coconut types

Annals of Tropical Research, 2007
Using a suitable medium for specific plant genotype greatly improves the efficiency of the in vitro culture method. The Visayas State University (VSU)-based National Coconut Research Center-Visayas (NCRC-V) evaluated the comparative suitability of the ...
Tessie C. Nuñez
doaj   +1 more source