Results 211 to 220 of about 486,388 (376)

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

IN VITRO ESTABLISHMENT OF Eucalyptus globulus HYBRID CLONES

, 2012
http://dx.doi.org/10.5902/198050986626O presente estudo teve como objetivos avaliar o comportamento de clones de Eucalyptus grandis W.Hill ex Maiden x Eucalyptus globulus Labill e Eucalyptus urophylla S.T.Blake x Eucalyptus globulus Labill e o efeito de diferentes introduções in vitro (aos 30, 90 e 150 dias após a poda do ápice das minicepas) na fase ...
Borges, Silvano Rodrigues, Xavier, Aloisio, Oliveira, Leandro Silva de, Lopes, Aline Pontes, Otoni, Wagner Campos, Takahashi, Elizabete Keiko, Melo, Lucas Amaral de   +6 more
openaire   +1 more source

Growth regulator and axillary bud position effects on in vitro establishment of Vitis rotundifolia

, 1991
Sudarsono, R. Goldy
semanticscholar   +1 more source

Establishment of an a priori protocol for the implementation and interpretation of an in‐vitro testing battery for the assessment of developmental neurotoxicity

, 2020
S. Masjosthusmann, J. Blum, Kristina Bartmann, Xenia Dolde, Anna-Katharina Holzer, Lynn-Christin Stürzl, E. Keßel, N. Förster, A. Dönmez, J. Klose, M. Pahl, T. Waldmann, F. Bendt, J. Kisitu, Ilinca Suciu, Ulrike Hübenthal, A. Mosig, M. Leist, E. Fritsche   +18 more
semanticscholar   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Establishment of an Efficient Micropropagation System in <i>Anthurium</i> Hybrids Through <i>In Vitro</i> Callogenesis and Suspension Culture

, 2019
Ya-Ling Huang, Shih-Chang Yuan, Fure-Chyi Chen   +2 more
openalex   +2 more sources

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Cancer therapy-related cardiovascular aging: mechanisms, monitoring, and intervention strategies. [PDF]

Front Cardiovasc Med
Lin X, Wu Z, Liu Y, Liao X.
europepmc   +1 more source

In vitro establishment from mature nodal segments of Persian Lime (Citrus latifolia Tan.) [PDF]

Humberto Estrella‐Maldonado, Julio Ventura-Bello, Ricardo Santillán-Mendoza, Cristian Matilde-Hernández, Arianna Chan-León, Felipe Roberto Flores-de la Rosa   +5 more
openalex   +1 more source