Results 101 to 110 of about 670,418 (378)

A novel approach for the isolation and long-term expansion of pure satellite cells based on ice-cold treatment

Skeletal Muscle, 2021
Satellite cells (SCs) are muscle stem cells capable of regenerating injured muscle. The study of their functional potential depends on the availability of methods for the isolation and expansion of pure SCs with preserved myogenic properties after serial
Anna Benedetti, Gianluca Cera, Daniele De Meo, Ciro Villani, Marina Bouche, Biliana Lozanoska-Ochser   +5 more
doaj   +1 more source

Deciphering Acute Myeloid Leukemia Associated Transcription Factors in Human Primary CD34+ Hematopoietic Stem/Progenitor Cells

Cells, 2023
Hemato-oncological diseases account for nearly 10% of all malignancies and can be classified into leukemia, lymphoma, myeloproliferative diseases, and myelodysplastic syndromes. The causes and prognosis of these disease entities are highly variable. Most
Sophie Kreissig, Roland Windisch, Christian Wichmann   +2 more
doaj   +1 more source

The Outcome of Ex Vivo TIL Expansion Is Highly Influenced by Spatial Heterogeneity of the Tumor T-Cell Repertoire and Differences in Intrinsic In Vitro Growth Capacity between T-Cell Clones

Clinical Cancer Research, 2020
Purpose: During our efforts to develop tumor-infiltrating lymphocyte (TIL) therapy to counter the devastating recurrence rate in patients with primary resectable pancreatic ductal adenocarcinoma (PDA), we found that PDA TILs can readily be expanded in ...
I. Poschke, J. Hassel, Aaron Rodriguez-Ehrenfried, K. Lindner, Ignacio Heras-Murillo, L. Appel, J. Lehmann, T. Lövgren, S. Wickström, Claudia Lauenstein, J. Roth, Anna-Katharina König, J. Haanen, J. H. van den Berg, R. Kiessling, F. Bergmann, M. Flossdorf, O. Strobel, R. Offringa   +18 more
semanticscholar   +1 more source

A mechanistic approach to design smart scaffolds for tissue engineering [PDF]

, 2006
This thesis describes a library of novel 3D scaffolds designed and optimized for tissue engineering and regenerative medicine applications. Tissue engineering aims at restoring or regenerating a deamaged tissue by combining cells, derived from a patient ...
Moroni, Lorenzo
core   +1 more source

Memory NK cell features exploitable in anticancer immunotherapy [PDF]

, 2019
Besides their innate ability to rapidly produce effector cytokines and kill virus-infected or transformed cells, natural killer (NK) cells display a strong capability to adapt to environmental modifications and to differentiate into long-lived ...
Battella, Simone, Capuano, Cristina, Galandrini, Ricciarda, Palmieri, Gabriella, Pighi, Chiara, Santoni, Angela   +5 more
core   +2 more sources

Serum-free media for articular chondrocytes in vitro expansion

Chinese Medical Journal, 2013
Background In vitro chondrocyte expansion is a major challenge in cell-based therapy for human articular cartilage repair. Classical culture conditions usually use animal serum as a medium supplement, which raises a number of undesirable questions.
Xin-xin, Shao, Neil A, Duncan, Lin, Lin, Xin, Fu, Ji-ying, Zhang, Chang-long, Yu   +5 more
openaire   +2 more sources

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Bystander B cells rapidly acquire antigen receptors from activated B cells by membrane transfer: a novel mechanism for enhancing specific antigen presentation [PDF]

, 2007
The B cell antigen receptor (BCR) efficiently facilitates the capture and processing of a specific antigen for presentation on MHC class II molecules to antigen specific CD4+ T cells (1).
Ben J. C. Quah, Christopher R. Parish, Klaus I. Matthaei, Mark D. Hulett, Vaughan P. Barlow, Virginia McPhun   +5 more
core   +2 more sources

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source