Results 181 to 190 of about 670,418 (378)

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

In vitro expansion of single Lgr5+ liver stem cells induced by Wnt-driven regeneration

Nature, 2013
Meritxell Huch, C. Dorrell, S. Boj, J. V. Es, Vivian S. W. Li, M. Wetering, Toshiro Sato, K. Hamer, Nobuo Sasaki, M. Finegold, Annelise Haft, R. Vries, M. Grompe, H. Clevers   +13 more
semanticscholar   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Simultaneous Identification of Functional Antigen-Specific CD8⁺ and CD4⁺ Cells after In Vitro Expansion Using Elongated Peptides. [PDF]

Cells, 2022
Schuhmacher J, Kleemann L, Richardson JR, Rusch E, Rammensee HG, Gouttefangeas C.   +5 more
europepmc   +1 more source

Cotargeting TREM2 and IL2 pathways triggers multipronged anticancer immunity

Molecular Oncology, EarlyView.
Von Locquenghien et al. report that MiTE‐144, a triggering receptor expressed on myeloid cells 2 (TREM2) blocking antibody fused to interleukin‐2 (IL2) variant with tumour microenvironment restricted activation, demonstrates superior anticancer efficiency in a preclinical setting.
Isaure Vanmeerbeek, Jenny Sprooten, Abhishek D. Garg   +2 more
wiley   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Supplementary Figure 1 from Long-term <i>In vitro</i> Expansion Alters the Biology of Adult Mesenchymal Stem Cells [PDF]

, 2023
Reza Izadpanah, Deepak Kaushal, Christopher Kriedt, Fern Tsien, Bindiya Patel, Jason Dufour, Bruce A. Bunnell   +6 more
openalex   +1 more source

A study on the effect of the number of expansion units in a microfluidic chip on hyaluronidase-free oocyte denudation in mammals

Journal of Electrical Bioimpedance
In Vitro Fertilization (IVF) and Intracytoplasmic Sperm Injection (ICSI) are well-known fertility treatments that, due to resource-intensive, high degree of expertise required, and frequent subpar performances, often yield in high costs for treatment ...
Dessouky Ashraf Hisham, EL-Hussieny Haitham, EL-Sherry Taymour Mohammed, Parque Victor, Fath El-Bab Ahmed M. R.   +4 more
doaj   +1 more source

In Vitro Expansion of Vδ1+ T Cells from Cord Blood by Using Artificial Antigen-Presenting Cells and Anti-CD3 Antibody. [PDF]

Vaccines (Basel), 2023
Hur G, Choi H, Lee Y, Sohn HJ, Kim SY, Kim TG.   +5 more
europepmc   +1 more source

Expansion of human gammadelta T cells after in vitro stimulation with Campylobacter jejuni [PDF]

, 2003
Ildiko Van Rhijn
openalex   +1 more source