Results 81 to 90 of about 670,418 (378)

Unlimited in vitro expansion of adult bi-potent pancreas progenitors through the Lgr5/R-spondin axis

EMBO Journal, 2013
Lgr5 marks adult stem cells in multiple adult organs and is a receptor for the Wnt‐agonistic R‐spondins (RSPOs). Intestinal, stomach and liver Lgr5+ stem cells grow in 3D cultures to form ever‐expanding organoids, which resemble the tissues of origin ...
Meritxell Huch, P. Bonfanti, S. Boj, Toshiro Sato, Cindy J. M. Loomans, M. van de Wetering, M. Sojoodi, Vivian S. W. Li, Jurian Schuijers, A. Gračanin, F. Ringnalda, H. Begthel, K. Hamer, J. Mulder, J. van Es, E. D. de Koning, R. Vries, H. Heimberg, H. Clevers   +18 more
semanticscholar   +1 more source

Glucocorticoid receptor signalling activates YAP in breast cancer [PDF]

, 2017
The Hippo pathway is an oncosuppressor signalling cascade that plays a major role in the control of cell growth, tissue homoeostasis and organ size. Dysregulation of the Hippo pathway leads to aberrant activation of the transcription co-activator YAP ...
Bertolio, Rebecca, Bicciato, Silvio, Cappuzzello, Elisa, Del Sal, Giannino, Forcato, Mattia, Ingallina, Eleonora, Mano, Miguel, Marotta, Carolina, Neri, Carmelo, Rosato, Antonio, Ruggeri, Naomi, Sorrentino, Giovanni, Zannini, Alessandro   +12 more
core   +3 more sources

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Prevalence, causes of blindness, visual impairment and cataract surgical services in Sindhudurg district on the western coastal strip of India

Indian Journal of Ophthalmology, 2014
Background : Konkan coast of India is geographically distinct and its pattern of blindness has never been mapped. Aim : To study the prevalence and causes of blindness and cataract surgical services in Sindhudurg district of West Coast.
Shailbala Patil, Parikshit Gogate, Siddharth Vora, Sachin Ainapure, Ramkrishna N Hingane, Anil N Kulkarni, B R Shammanna   +6 more
doaj   +1 more source

Human Mesenchymal Stem Cells Retain Multilineage Differentiation Capacity Including Neural Marker Expression after Extended In Vitro Expansion

PLoS ONE, 2015
The suitability of human mesenchymal stem cells (hMSCs) in regenerative medicine relies on retention of their proliferative expansion potential in conjunction with the ability to differentiate toward multiple lineages.
R. Okolicsanyi, E. Camilleri, Lotta E. Oikari, Chieh Yu, S. Cool, A. V. van Wijnen, L. Griffiths, L. Haupt   +7 more
semanticscholar   +1 more source

Hematopoietic (stem) cells—The elixir of life?

FEBS Letters, EarlyView.
The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo, Jonah Anderson, Emilie Dinh Vedrenne, Noël Yeh Martín, Jette Lengefeld   +4 more
wiley   +1 more source

Aggressive posterior retinopathy of prematurity in infants ≥1500 g birth weight

Indian Journal of Ophthalmology, 2014
In this retrospective case series, we report the spectrum and outcomes of aggressive posterior retinopathy of prematurity (APROP) in infants ≥1500 g birth weight. Twenty-nine eyes of 15 infants are included.
Gaurav Sanghi, Mangat R Dogra, Deeksha Katoch, Amod Gupta   +3 more
doaj   +1 more source

Expansion Improved the Physical and Chemical Properties and In Vitro Rumen Digestibility of Buckwheat Straw

Animals, 2023
The hard texture and poor palatability of straw are important factors that hinder its application in feed. Expansion is a technology that can improve the utilization of biomass, but few studies have comprehensively revealed how to change physicochemical ...
Xiaohui Cao, Sasa Zuo, Yanli Lin, Rui Cai, Fuyu Yang, Xuekai Wang, Chuncheng Xu   +6 more
doaj   +1 more source

Joint fitting reveals hidden interactions in tumor growth [PDF]

, 2014
Tumor growth is often the result of the simultaneous development of two or more cancer cell populations. Their interaction between them characterizes the system evolution.
Barberis, Lucas, Condat, Carlos Alberto, Pasquale, Miaguel Ángel   +2 more
core   +4 more sources

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source