Results 181 to 190 of about 805,984 (229)
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SHORT IN VITRO HALF‐LIFE OF THYMOPOIETIN 32–36 PENTAPEPTIDE IN HUMAN PLASMA
International Journal of Peptide and Protein Research, 1979Thymopoietin32–36(TP5) is a synthetic pentapeptide that has the biological activity of its parent molecule, the 49 amino acid thymic hormone thymopoietin. Tritiated thymopoietin32–36(3H‐TP5) was prepared by reductive tritiation of dibromotyrosyl‐TP5. The stability of3H‐TP5 in human plasma was studied by analyzing samples by thin‐layer chromatography at
J P, Tischio +4 more
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In vitro half-life of 14-C-tryptamine in whole blood of drug-free chronic schizophrenic patients
American Journal of Psychiatry, 1977The authors found higher in vitro 14C-tryptamine half-lives in the blood of 10 drug-free chronic schizophrenic patients than in the blood of 13 mentally normal control subjects. This finding was negatively correlated for both groups with platelet MAO activity.
E F, Domino, S, Gahagan
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Influence of ampicillin elimination half-life on in-vitro bactericidal effect
Journal of Antimicrobial Chemotherapy, 1985Escherichia coli ATCC 12407 was exposed in an in-vitro kinetic model to multiple dose ampicillin regimens differing in simulated drug elimination half-life but with equal dosage intervals and similar dose levels. Bacterial sensitivity was monitored during drug exposure. Greater bactericidal effect was observed with long half-life regimens.
C A, White, R D, Toothaker
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Microchemical Journal, 2020
Abstract Metabolic stability plays a crucial role in assessing the safety of potential drug candidates. Assays to designate in vitro half-life are well established and are focused on phase I metabolism using human liver microsomes. However, such an assay can easily be modified to include phase II metabolism.
Szymon Ulenberg +6 more
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Abstract Metabolic stability plays a crucial role in assessing the safety of potential drug candidates. Assays to designate in vitro half-life are well established and are focused on phase I metabolism using human liver microsomes. However, such an assay can easily be modified to include phase II metabolism.
Szymon Ulenberg +6 more
semanticscholar +3 more sources
Molecular Pharmaceutics, 2019
A large variety of drugs bind effectively to melanin, and this binding influences their ocular pharmacokinetic and distribution profiles. We aimed to establish a correlation between in vitro melanin binding and in vivo ocular pharmacokinetics (PK). The extent of melanin binding in vitro was determined for a set of model drugs; binding kinetics and ...
Paulina Jakubiak +3 more
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A large variety of drugs bind effectively to melanin, and this binding influences their ocular pharmacokinetic and distribution profiles. We aimed to establish a correlation between in vitro melanin binding and in vivo ocular pharmacokinetics (PK). The extent of melanin binding in vitro was determined for a set of model drugs; binding kinetics and ...
Paulina Jakubiak +3 more
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Drug Development and Industrial Pharmacy, 2011
Lipid-based drug delivery systems are widely used for enhancing the solubility of poorly water soluble drugs in the gastro-intestinal tract. Following oral intake, lipid systems undergo digestion in the stomach as well as the intestine. Lipolysis is here a complex process at the oil/water interface, influenced by numerous factors.To study the ...
Yvonne E, Arnold +2 more
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Lipid-based drug delivery systems are widely used for enhancing the solubility of poorly water soluble drugs in the gastro-intestinal tract. Following oral intake, lipid systems undergo digestion in the stomach as well as the intestine. Lipolysis is here a complex process at the oil/water interface, influenced by numerous factors.To study the ...
Yvonne E, Arnold +2 more
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Drug Metabolism and Disposition, 1999
Twenty-nine drugs of disparate structures and physicochemical properties were used in an examination of the capability of human liver microsomal lability data ("in vitro T(1/2)" approach) to be useful in the prediction of human clearance. Additionally, the potential importance of nonspecific binding to microsomes in the in vitro incubation milieu for ...
R. Obach
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Twenty-nine drugs of disparate structures and physicochemical properties were used in an examination of the capability of human liver microsomal lability data ("in vitro T(1/2)" approach) to be useful in the prediction of human clearance. Additionally, the potential importance of nonspecific binding to microsomes in the in vitro incubation milieu for ...
R. Obach
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Comparison of rate of Hepatic Metabolismin vitroand Half-Life for Antipyrinein vivoin Three Species
Xenobiotica, 19791. A radiometric assay for the total metabolism of antipyrine in vitro by hepatic microsomal preparations has been developed. 2. Apparent Km and V values for the process were determined in rats, rabbits and in a marsupial (the quokka; Setomix brachyurus).
McManus, M. E., Ilett, K. F.
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