Results 201 to 210 of about 423,855 (249)

Comparative pharmacokinetics of trimethoprim-sulfadiazine and trimethoprim-sulfamethoxazole in dogs. [PDF]

BMC Vet Res
Ekstrand C, Löwgren M, Erkas M, Devreese M, De Baere S, Vo-Thanh J, Ferran AA.   +6 more
europepmc   +1 more source

RNF138‐Mediated Ubiquitination and Degradation of NS5 Restricts Tick‐Borne Encephalitis Virus Infection

Advanced Science, EarlyView.
Host‐specific compatibility between RNF138‐like proteins and flavivirus NS5 determines NS5 stability. Mammalian RNF138 but not arthropod homologs recognizes and induces conserved NS5/RdRp K48‐linked ubiquitination and proteasomal degradation, thereby restricting viral replication. Ectopic RNF138 in mice attenuates TBEV‐induced pathogenesis. (Created in
Jialiang Sun, Weijing Yang, Hao Zhou, Shuai Li, Xin Jiang, Jianyang Gu, Wenyan Zhang   +6 more
wiley   +1 more source

Rational design and preclinical evaluation of elastin-like polypeptide micelle nanoparticles for drug delivery. [PDF]

Front Bioeng Biotechnol
Tofik A, Zhang Y, Volpe C, Wang J.
europepmc   +1 more source

Targeting Dnmt3a/m5C/RelA Axis Attenuates Microglia Inflammatory Response and Improves Postoperative Recovery in Chronic Compressive Cervical Spinal Cord Injury

Advanced Science, EarlyView.
A pro‐inflammatory microglial subset persists after decompression in chronic compressive cervical spinal cord injury and shows enhanced Dnmt3a‐driven m5C signaling. By stabilizing RelA mRNA, this axis sustains NF‐κB activation and postoperative neuroinflammation.
Tianyu Qin, Yuan Jiang, Yongheng Xie, Huanwei Qu, Wenbin Yan, Jingle Chen, Yining Chen, Huayi Li, Naibo Feng, Jiajun Wu, Chao Zhang, Zhengqi Huang, Ming Shi, Zhihuai Deng, Guozhi Xiao, Houqing Long   +15 more
wiley   +1 more source

Tunable acoustic rotation for deep biophysical phenotyping of preclinical Alzheimer's disease. [PDF]

Mater Today Bio
Wang Y, Quan Y, Zhou S, Zhou Y.
europepmc   +1 more source

Molecular Mobility of N‐Acetylgalactosamine‐Modified Cyclodextrins on a Polyrotaxane for Highly Efficient Liver Targeting of Antibody Chimeras and Genome‐Editing Ribonucleoproteins

Advanced Science, EarlyView.
Monovalent N‐acetylgalactosamine (GalNAc)‐modified polyrotaxane enables efficient liver targeting by utilizing ligand mobility. The sliding and rotating cyclic components i.e., cyclodextrin in the polyrotaxane dynamically cluster GalNAc moieties, thereby mimicking trivalent interactions with asialoglycoprotein receptors.
Toru Taharabaru, Keiichi Motoyama, Yuting Wen, Zhongxing Zhang, Xuehao Tian, Jun Li, Taishi Higashi   +6 more
wiley   +1 more source

Theranostics of Bone Metastases: The Role and Prospects of Bisphosphonate Radiopharmaceuticals. [PDF]

Pharmaceuticals (Basel)
Qian Y, Yin G, Jiang Y, Han P, Zhang J.
europepmc   +1 more source

Toxicokinetic-Oriented Assessment of Nepetalactone Using In Silico ADMET Modeling, In Vitro Rat and Human Liver Microsomes, and UHPLC-MS/MS Metabolite Characterization. [PDF]

Toxics
Stoica NB, Cascajosa-Lira A, Morea A, Catunescu GM, Hornedo-Ortega R, Guzmán-Guillén R.   +5 more
europepmc   +1 more source

HMB-002: a monovalent antibody that elevates circulating VWF and FVIII levels for treatment of von Willebrand disease. [PDF]

Blood Adv
Häger M, Zivkovic M, Gandhi PS, Rasmussen C, Bonvoisin C, Harrison RA, Poulsen E, Huskens D, Roest M, Ferrara F, Naretto A, Renaud L, Olsen OH, Eskesen NO, Holten-Andersen L, Malladi R, Rea CJ, Sørensen B, Urbanus RT, Østergaard H.   +19 more
europepmc   +1 more source

Radiopharmaceutical: An Update and Comparison of Preclinical Investigation Result of Alpha and Beta Emitter Radioisotope. [PDF]

Drug Des Devel Ther
Luhung A, Hasanah AN, Ramdhani D.
europepmc   +1 more source