Results 161 to 170 of about 701,007 (399)

Supplementation with low concentrations of melatonin improves nuclear maturation of human oocytes in vitro [PDF]

, 2013
Duo Wei, C L Zhang, Juanke Xie, Xiaobing Song, Baoli Yin, Qi Liu, Lin Hu, Haoying Hao, Jiaxuan Geng, Peng Wang   +9 more
openalex   +1 more source

Wnt/beta-catenin signaling controls development of the blood–brain barrier [PDF]

, 2009
The blood–brain barrier (BBB) is confined to the endothelium of brain capillaries and is indispensable for fluid homeostasis and neuronal function. In this study, we show that endothelial Wnt/beta-catenin (beta-cat) signaling regulates induction and ...
Babbage, Jane, Bangsow, Thorsten, Corada, Monica, Czupalla, Cathrin Jacqueline, Dejana, Elisabetta, Felici, Angelina, Fruttiger, Marcus, Gerhardt, Holger, Liebner, Stefan, Melchner, Harald von (Prof. Dr.), Plate, Karl H., Reis, Marco, Taddei, Andrea, Taketo, Makoto Mark, Wolburg, Hartwig   +14 more
core  

Patient and Disease-Specific Induced Pluripotent Stem Cells for Discovery of Personalized Cardiovascular Drugs and Therapeutics. [PDF]

, 2020
Human induced pluripotent stem cells (iPSCs) have emerged as an effective platform for regenerative therapy, disease modeling, and drug discovery.
Chandy, Mark, Paik, David T, Wu, Joseph C   +2 more
core  

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Tingkat Maturasi dan Fertilisasi Oosit Domba yang Dimaturasi dalam Media dengan Imbuhan b-Mercaptoethanol Secara In Vitro (IN VITRO MATURATION AND FERTILIZATION RATE AT SHEEP OOCYTES MATURATED IN MEDIA WITH b-MERCAPTOETHANOL)

Jurnal Veteriner, 2016
The objectives of this study to evaluate the effect of b-mercaptoethanol addition in maturation mediumon maturation and fertilization rate of sheep oocytes in vitro.
Okky Adi Bintara, Mohamad Agus Setiadi, Ni Wayan Kurniani Karja   +2 more
doaj  

In vitro affinity maturation of a natural human antibody overcomes a barrier to in vivo affinity maturation [PDF]

, 2014
Bing Li, Ashley E. Fouts, Katharina Stengel, Peng Luan, Michael Dillon, Wei‐Ching Liang, Becket Feierbach, Robert F. Kelley, Isidro Hötzel   +8 more
openalex   +1 more source

Differential and Temporal Immunomodulation of alpha4 Integrins on CD4+ Memory Cells by Bordetella pertussis and Bordetella parapertussis [PDF]

, 2012
Pertussis, caused by Bordetella pertussis (B. pertussis), is reemerging worldwide due to vaccine inefficacy. The hallmarks of infection are extreme lymphocytosis and delayed recovery, which are partially associated with pertussis toxin.
Ravindra, Dipti
core   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Clinical Assisted Reproduction: Cumulus Cell Contribution to Cytoplasmic Maturation and Oocyte Developmental Competence In Vitro [PDF]

, 2001
Hassan Aly Hassan
openalex   +1 more source

Outcomes of clinical in vitro maturation programs for treating infertility in hyper responders: a systematic review [PDF]

, 2023
Lan N. Vuong, Toan D. Pham, Tuong M. Ho, Michel De Vos   +3 more
openalex   +1 more source