Results 271 to 280 of about 332,871 (312)
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Modeling the profibrotic microenvironmentin vitro: model validation
Biochemical and Biophysical Research Communications, 2023Establishing the molecular and cellular mechanisms of fibrosis requires the development of validated and reproducible models. The complexity ofin vivomodels challenges the monitoring of an individual cell fate, in some cases making it impossible.
Olga Grigorieva +7 more
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Engineering mammary tissue microenvironments in vitro
2022Breast cancer is the most common cancer in women worldwide, and while screening, diagnostic tools and treatments have improved over the decades, many women still succumb to the disease. The heterogeneity of breast cancer and the many subtypes and sites of origin mean that it is remains a difficult disease to fully elucidate.
Clegg, Julien +4 more
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Modeled vascular microenvironments: immune-endothelial cell interactions in vitro
Drug Delivery and Translational Research, 2021The advancement of in vitro techniques enables a better understanding of biological processes and improves drug screening platforms. In vitro studies allow for enhanced observation of cell behavior, control over the mimicked microenvironment, and the ability to use human cells.
Justin Silberman +4 more
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Study of haemopoietic microenvironment in vitro
Nature, 1976THE concept of the haemopoietic inductive microenvironment as first proposed by Curry and Trentin1 has been amply confirmed by experiment. One salient feature of this concept relates to the role of the mouse spleen in promoting erythropoiesis rather than granulopoiesis. For example, in the clonal growth of transplanted bone marrow cells, the spleens of
G E, Van Zant, E, Goldwasser, J M, Baron
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In vitro modeling of the prostate cancer microenvironment
Advanced Drug Delivery Reviews, 2014Prostate cancer is the most commonly diagnosed malignancy in men and advanced disease is incurable. Model systems are a fundamental tool for research and many in vitro models of prostate cancer use cancer cell lines in monoculture. Although these have yielded significant insight they are inherently limited by virtue of their two-dimensional (2D) growth
Stuart J. Ellem +2 more
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Studies on the In Vitro Microenvironment in Man
1983In a preliminary manner, the data presented here characterize some features of MSC and their progenitors. The progenitors, at least in chronic myelogenous leukemia, are derived from the neoplastic pluripotent stem cell that also differentiates along lymphoid and myeloid pathways.
J W, Singer, A, Keating
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In Vitro Reconstruction of Brain Tumor Microenvironment
BioChip Journal, 2019The cancer cells in brain tumors interact with their microenvironment, which includes stromal cells, the extracellular matrix (ECM), and the physical properties of tissues. The reciprocal interaction between cancer cells and the surrounding microenvironment regulates the biological behavior of cancer cells.
Ilkyoo Koh, Pilnam Kim
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Epidermal barrier reaction to an in vitro psoriatic microenvironment
Experimental Cell Research, 2017Keratinocytes (KCs) and Langerhans cells (LCs) contribute to create the epidermal barrier. To form a functional epidermis, KCs express filaggrin and Toll-like Receptors (TLRs). LCs are the first line of epidermal defence and can be activated by interleukin (IL)-17 and Tumor Necrosis Factor (TNF)-alpha.
Donetti E +8 more
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Modeling the chronic lymphocytic leukemia microenvironmentin vitro
Leukemia & Lymphoma, 2016Microenvironments within the lymph node and bone marrow promote proliferation and drug resistance in chronic lymphocytic leukemia (CLL). Successful treatment of CLL must therefore target the leukemic cells within these compartments. A better understanding of the interaction between CLL cells and the tumor microenvironment has led to the development of ...
Kyle, Crassini +3 more
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