Results 281 to 290 of about 332,871 (312)
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Studies of the Erythroid Inductive Microenvironment in Vitro
1977Hemopoietic inductive microenvironments, associated with the stroma of blood-forming tissues, demonstrate specificity in regulating blood cell formation (7, 8, 25). The inductive influences of microenvironments are radio-resistant, and their distribution can be mapped in radiated mice or rats injected with pluripotent stem cells (14).
Gary van Zant +2 more
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Stromal Microenvironment of Human Fetal Hematopoiesis: In vitro Morphologic Studies
Pathobiology, 1994The stromal microenvironment is essential for the proliferation and differentiation of hematopoietic progenitors. The features of stroma which contribute to normal hematopoietic stem cell ontogeny or to observed differences in hematopoiesis between fetal and adult hematopoietic organs remain to be fully characterized.
C A, Bethel +3 more
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In vitro microenvironments to study breast cancer bone colonisation
Advanced Drug Delivery Reviews, 2014Bone metastasis occurs frequently in patients with advanced breast cancer and is a major cause of morbidity and mortality in these patients. In order to advance current therapies, the mechanisms leading to the formation of bone metastases and their pathophysiology have to be better understood.
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3D in vitro Models to Mimic the Tumor Microenvironment
2021A completely different approach to create a biologically relevant in vitro model is the culture of biological samples themselves in the form of tumor tissues or slices. In the recent years, two approaches have emerged more or less in parallel to create 3D in vitro models that are easy to control and reproduce while maintaining a high biological ...
Alexander, Marcel +3 more
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Haemopoietic microenvironments in vitro: ultrastructural aspects.
Ciba Foundation symposium, 1981Haemopoietically active long-term bone marrow cultures from several species have been investigated ultrastructurally. Human, tree shrew and mouse cultures generally support granulopoiesis, although recently it has been possible to convert a granulopoietic mouse culture to extensive erythropoiesis.
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Characterization of the in vitro stromal microenvironment of human bone marrow
The International Journal of Cell Cloning, 1986Utilizing long-term in vitro culture techniques, we characterized the cellular composition and functional attributes of the human in vitro bone marrow stromal microenvironment. Morphologic, specific cytochemical and immunologic methods demonstrated that the marrow stromal adherent layer (AL) reached confluency at two to three weeks, and was comprised ...
E S, Strobel, R E, Gay, P L, Greenberg
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Changes of microenvironment in an in vitro co-culture system
2015For the enhanced understanding of fundamental cancer biology and improving molecular diagnostics and therapeutics, the role of the microenvironment during the initiation and progression of carcinogenesis is thought to be of critical importance (1, 2).
Salvatore, Viviana +5 more
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Microfluidic device for recreating a tumor microenvironment in vitro.
Journal of visualized experiments : JoVE, 2012We have developed a microfluidic device that mimics the delivery and systemic clearance of drugs to heterogeneous three-dimensional tumor tissues in vitro. Nutrients delivered by vasculature fail to reach all parts of tumors, giving rise to heterogeneous microenvironments consisting of viable, quiescent and necrotic cell types.
Bhushan J, Toley +3 more
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Cell microenvironment and carcinogenesis in vivo and in vitro.
IARC scientific publications, 1984Normal cells of many types are located in vivo and in vitro at the boundary between the two compartments of their microenvironment: between the noncellular surface (artificial substrates and cell-made matrices) and the humoral medium. Altered reactions to both these parts of microenvironment and to neighbouring cells are characteristic of neoplastic ...
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Embryo development in vitro in microenvironment culture
JBRA Assisted Reproduction, 2008Condesmar Marcondes de Oliveira Filho +5 more
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