Results 91 to 100 of about 118,389,530 (261)

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

A human relevant in vitro alveolar epithelial barrier model to assess inhaled pollutant hazard

Scientific Reports
Relevant in vitro models could reduce the requirement for in vivo testing and allow higher throughput for imperative toxicological or pharmaceutical hazard testing.
Joshua W. P. Bateman, Kirsty Meldrum, Sarah M. Mitchell, Ulla Vogel, Martin J. D. Clift   +4 more
doaj   +1 more source

Cell microencapsulation techniques for cancer modelling and drug discovery

Artificial Cells, Nanomedicine, and Biotechnology
Cell encapsulation into spherical microparticles is a promising bioengineering tool in many fields, including 3D cancer modelling and pre-clinical drug discovery.
Lisa Barrett, Karen Coopman
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Changes in acetylation of lysine 5 on histone H4 in canine oocytes following in vitro maturation

, 2017
Post-translational modifications of histones, such as acetylation, are involved in regulating chromatin remodelling and gene expression. Proper in vitro maturation (IVM) of canine oocytes, for many reasons, is up to now inefficient.
Alves, A. E., Pires-Buttler, E. A. [UNESP], Arnold, D. R., Motheo, T. F. [UNESP], Lopes, F. L. [UNESP], Vicente, W. R.R. [UNESP], Padilha-Nakaghi, L. C. [UNESP], Apparicio, M.   +7 more
core   +1 more source

Supplementation of fetal bovine serum alters histone modification H3R26me2 during preimplantation development of in vitro produced bovine embryos [PDF]

, 2015
In vitro production (IVP) of bovine embryos is not only of great economic importance to the cattle industry, but is also an important model for studying embryo development.
Corrêa, Carolina A.P. [UNESP], Laura L.G. Lorena, João C.T. Penteado, Mingoti, Gisele, Penteado, João C.T., Lorena, Laura L.G., Arnold, Daniel R., Rossi, Guilherme F. [UNESP], Daniel R. Arnold, Guilherme F. Rossi, Flavia L. Lopes, Lopes, Flavia L. [UNESP], Rossi, Guilherme F., Ifran, Aderson M. [UNESP], Carolina A.P. Corrêa, Gaspar, Roberta C., Mingoti, Gisele [UNESP], Gisele Mingoti, Roberta C. Gaspar, Lorena, Laura L.G. [UNESP], Aderson M. Ifran, Corrêa, Carolina A.P., Ifran, Aderson M., Lopes, Flavia L., Penteado, João C.T. [UNESP], Gaspar, Roberta C. [UNESP]   +25 more
core   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Pergamon Acropolis Model

, 1950
Detail, Temple of Dionysus at lowest point, center, Temple of Trajan (2nd century CE) in courtyard, theater, lower right; Pergamon was an ancient Greek city in Asia Minor (now Bergama, Turkey), later part of the Roman Empire.
unknown (German model maker)
core  

Assessment of the human epidermis model SkinEthic RHE for in vitro skin corrosion testing of chemicals according to new OECD TG 431

, 2006
Based on two successfully completed ECVAM validation studies for in vitro skin corrosion testing of chemicals, the National Co-ordinators of OECD Test Guideline Programme endorsed in 2002 two new test guidelines: TG 430 'Transcutaneous Electrical ...
Whittingham, A., Kandarova, H., Schmidt, E., Remmele, M., Guest, R., Spielmann, H., Warren, N., Traue, D., Gamer, A. O., Liebsch, M., Wever, B. de, Kaufmann, T., Wittmer, E., Rosdy, M., Genschow, E.   +14 more
core   +1 more source

Application of In Vitro Digestion Models in the Evaluation of Dietary Supplements

Foods
Nowadays, dietary supplements are a permanent part of our diet. Using various simulated in vitro digestive models, the bioavailability of dietary supplement ingredients has also been investigated.
Justyna Ośko, Katarzyna Nasierowska, Małgorzata Grembecka   +2 more
doaj   +1 more source