Results 81 to 90 of about 2,928,750 (309)

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Trackability Measurement of Coronary Stent in a Coronary Vessel Modell [PDF]

, 2008
The EN 14299 standard describes in vitro tests of stent and stent system which are specified more precisely and cover a number of additional parameters.
Dobránszky, János, Szabadíts, Péter
core  

Mechanical cell-matrix feedback explains pairwise and collective endothelial cell behavior in vitro

, 2014
In vitro cultures of endothelial cells are a widely used model system of the collective behavior of endothelial cells during vasculogenesis and angiogenesis. When seeded in an extracellular matrix, endothelial cells can form blood vessel-like structures,
LaValley, Danielle J., Merks, Roeland M. H., Reinhart-King, Cynthia, Rens, Elisabeth G., van Oers, René F. M.   +4 more
core   +3 more sources

Biocompatibility of a lab-on-a-pill sensor in artificial gastrointestinal environments [PDF]

, 2006
n this paper, we present a radiotelemetry sensor, designed as a lab-in-a-pill, which incorporates a two-channel microfabricated sensor platform for real-time measurements of temperature and pH.
Cooper, J.M., Cumming, D.R.S., Johannessen, E.A., Wang, L., Wyse, C.   +4 more
core   +1 more source

Theme 3 In vitro experimental models [PDF]

Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, 2019
Background: Ongoing disease gene discoveries continue to drive our understanding of the molecular and cellular mechanisms underlying ALS. Causative genes from 60% of ALS families have been identified using modern genetic techniques, but the causal gene defect is yet to be identified in the remaining 40% of families.
Shu, Yang, Sharlynn, Wu, Jennifer, Fifita, Emily, McCann, Sandrine Chan Moi, Fat, Jasmin, Galper, Sarah, Freckleton, Kathrine Y, Zhang, Ian P, Blair   +8 more
openaire   +2 more sources

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Tadalafil modulates aromatase activity and androgen receptor expression in a human osteoblastic cell in vitro model [PDF]

, 2016
Purpose Phosphodiesterase type-5 inhibitor (PDE5i) tadalafil administration in men with erectile dysfunction is associated with increased testosterone/estradiol ratio, leading to hypothesize a potential increased effect of androgen action on target ...
Aversa, Antonio, Bimonte, V. M., Fittipaldi, Simona, Francomano, Davide, Greco, E. A., Lenzi, Andrea, Migliaccio, S., Papa, V., Wannenes, F.   +8 more
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

An in vitro Model of Human Retinal Detachment Reveals Successive Death Pathway Activations

Frontiers in Neuroscience, 2020
Purposewas to create an in vitro model of human retinal detachment (RD) to study the mechanisms of photoreceptor death.MethodsHuman retinas were obtained through eye globe donations for research purposes and cultivated as explants.
Jelena Potic, Jelena Potic, Jelena Potic, Martial Mbefo, Adeline Berger, Michael Nicolas, Dana Wanner, Corinne Kostic, Alexandre Matet, Alexandre Matet, Francine Behar-Cohen, Francine Behar-Cohen, Alexandre Moulin, Yvan Arsenijevic   +13 more
doaj   +1 more source

Neoplastic transformation of porcine mammary epithelial cells in vitro and tumor formation in vivo. [PDF]

, 2015
BackgroundThe mammary glands of pigs share many functional and morphological similarities with the breasts of humans, raising the potential of their utility for research into the mechanisms underlying normal mammary function and breast carcinogenesis ...
Borowsky, AD, Cardiff, RD, Hovey, RC, Manjarin, R, Rowson-Hodel, AR, Trott, JF   +5 more
core