Results 221 to 230 of about 118,389,530 (261)

Blood product supplementation modulates clotting kinetics, mechanics, and fibrin architecture in an in vitro model of trauma-induced coagulopathy. [PDF]

Thromb Res
Gosselin AR, Ahmad S, Hanna JS, Goswami J, Tutwiler V.   +4 more
europepmc   +1 more source

Integrated PANoptosis Profiling Identifies Immunosuppressive Subtypes and a Prognostic Signature With Functional Validation of MLKL in Glioblastoma

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The prognosis of glioblastoma (GBM) remains highly unfavorable, largely due to high tumor heterogeneity and an immunosuppressive microenvironment. However, the functional role of PANoptosis in this context is poorly understood. Methods Patients were stratified via K‐means clustering. A risk score model was constructed using prognosis‐
Langfei Tian, Minghui Zhao, Yuanbo Hu, Kaiyue Wang, Haiguang Liu, Zetong Bai, Kebin Zheng   +6 more
wiley   +1 more source

SURVIVAL OF VITRIFIED IN VITRO AND IN VIVO PRODUCED OVINE BLASTOCYSTS

, 2000
DATTENA M., CAPPAI P. SURVIVAL OF VITRIFIED IN VITRO AND IN VIVO PRODUCED OVINE B.L.A.S.T.O.C.Y.S.T.S. THERIOGENOLOGY, LOI, Pasqualino, PTAK, Grazyna   +3 more
core   +1 more source

Endothelial-derived extracellular vesicles impair human pulmonary microvascular cell function in an in vitro model of sepsis-induced acute lung injury. [PDF]

Am J Physiol Lung Cell Mol Physiol
Cohen M, Haigis L, Blum RC, Sherman-Roe A, Pereira M, Chichger H, Ventetuolo CE, Liang OD, Harrington EO.   +8 more
europepmc   +1 more source

Region Specific miRNA–mRNA Networks in Gray and White Matter Lesions of Progressive Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Multiple sclerosis (MS) is a neurodegenerative demyelinating disease of the central nervous system. This study aimed to identify micro‐RNA (miRNA)–mRNA regulatory networks underlying region‐specific molecular mechanisms in white matter and gray matter lesions in progressive MS.
Adya Sapra, Nagendra K. Rai, Timothy D. Niepokny, Haley Courtney, Ajai Tripathi, Ranjan Dutta   +5 more
wiley   +1 more source

Validation and Testing of an In Vitro Model to Study Medical Treatments for Anterior Urethral Stricture Disease: Assessing the Potential Efficacy of Phosphodiesterase-4 Inhibition and Testosterone. [PDF]

Urology
Lozano LP, Volk MJ, Miller CD, Berg JE, Allamargot C, Schlaepfer CH, Kurtzman JT, Christensen MB, Myers JB, Hertz AM, Swanton AR, Tucker BA, Erickson BA.   +12 more
europepmc   +1 more source

Re‐Purposing Sapropterin (Kuvan) for ACTA2‐Related Multisystemic Smooth Muscle Dysfunction Syndrome: A Translational Mechanistic and First‐In‐Human Therapeutic Report

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Multisystemic smooth muscle dysfunction syndrome (MSMDS) is an ultra‐rare, ACTA2‐related disorder characterized by severe cerebrovascular disease, aortic aneurysms, and smooth muscle dysfunction. Using molecular dynamics simulations and in silico drug screening, we identified that sapropterin dihydrochloride (Kuvan) is a candidate capable of ...
Moran Hausman‐Kedem, Noa Bielopolski, Vijai Krishnan, Shane Wald‐Altman, Shelly I Shrian, Omer Bar‐Yosef, Livia Kapusta, Claire Shamber, Patricia L. Musolino, Miguel Weil   +9 more
wiley   +1 more source

Comparative mechanical analysis of collagen membranes derived from different tissues in an in vitro model simulating membrane-stabilized horizontal GBR. [PDF]

BMC Oral Health
Bai X, Xue Y, Li J, Liu Y, Ye Z, Yan H, Zhou Y.   +6 more
europepmc   +1 more source

Augmenting and Assaying Nav1.1 Protein Quantity for Dravet Syndrome Therapy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Dravet Syndrome (DS) is a developmental and epileptic encephalopathy predominantly caused by heterozygous loss‐of‐function variants in SCN1A, which encodes Nav1.1. Conserved upstream open reading frames (uORFs) in SCN1A were validated to regulate translation in reporter assays, demonstrating the therapeutic viability of increasing Nav1.1 from ...
Aiswarya Saravanan, Jordan Safran, Anna Loughman, Grace Lin, Shivanshi Vaid, Dana Allababidi, Peter M. Tessier, Louis T. Dang   +7 more
wiley   +1 more source

Investigating the Antioxidant and Immunomodulatory Effects of Quercetin Using Porcine PBMCs as an Inflammatory In Vitro Model. [PDF]

Antioxidants (Basel)
Somogyi F, Pézsa NP, Jerzsele Á, Németh J, Harmat L, Farkas O.   +5 more
europepmc   +1 more source