Results 201 to 210 of about 2,928,750 (309)

Establishment of an Advanced In Vitro Model for Pseudoexfoliation Syndrome and Glaucoma. [PDF]

Invest Ophthalmol Vis Sci
Pulasani S, Zenkel M, Lämmer R, Jünemann A, Gießl A, Korn K, Kruse FE, Pasutto F, Schlötzer-Schrehardt U.   +8 more
europepmc   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

In Vitro Model of the Human Blood-Brain Barrier to Explore HTLV-1 Immunopathogenesis. [PDF]

Curr Issues Mol Biol
Guimarães AB, Bernardo-Menezes L, Azevedo E, Agrelli A, Silva P, Sena M, Araújo Júnior W, Diniz G, Gaião WD, Rodrigues C, Cavalcante M, Castellano LR, Souza J, Magalhães P, Vallinoto AC, Morais C.   +15 more
europepmc   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Neuroprotective Effects of the Combination of Green Tea, Saffron, Docosahexaenoic Acid, and α-Lipoic Acid in an In Vitro Model of Parkinson's Disease. [PDF]

Mol Neurobiol
Galla R, Mulè S, Battaglia S, Curti V, Ranieri FR, Parini F, Uberti F.   +6 more
europepmc   +1 more source

OA in vitro models

This deliverable will identify the most faithful in vitro model of OA-like changes between trauma-induced OA and inflammatory cytokines signalling. Furthermore, it will validate the use of engineered constructs for in vitro high throughput analysis of OA severity and progression in relation to local cellular responses.
openaire   +1 more source

One size does not fit all: An in vitro evaluation of the effects of bezafibrate and medroxyprogesterone acetate on human SH‐SY5Y and U‐87 MG cancer cells

FEBS Open Bio, EarlyView.
Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar, Francesco Michelangeli, Farhat Latif Khanim, Christopher Martin Bunce, William Eustace Basil Johnson   +4 more
wiley   +1 more source

Effects of Chlorogenic Acid on Cellular Senescence in an In Vitro Model of 3T3-L1 Murine Adipocytes. [PDF]

Molecules
Molonia MS, Salamone FL, Trischitta S, Saija A, Cimino F, Speciale A.   +5 more
europepmc   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Lithium-Induced Modulation of Proliferation and Apoptosis in an In Vitro Model of Colorectal Cancer. [PDF]

Int J Mol Sci
Villegas-Vázquez EY, Becerril-Vigueras XP, Leyva-Gómez G, Porras-Vázquez SA, Jiménez-Fernández LA, Almanza-Torres JM, Bustamante-Montes LP, Rodríguez-Morales M, Trujillo-Condes VE, de la Torre-Núñez M, Tinoco-Torres BR, Herrera-Mundo N, Murillo-González FE, Reyes-Hernández OD, Figueroa-González G.   +14 more
europepmc   +1 more source