Results 111 to 120 of about 1,276,228 (308)

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Induction of apoptosis and growth inhibition by silodosin and abiraterone acetate in PC-3 human prostate cancer cells [PDF]

Investigative and Clinical Urology
Purpose: Prostate cancer that progresses despite androgen deprivation therapy, known as metastatic castration-resistant prostate cancer (mCRPC) is notoriously difficult to treat.
Lukman Hakim , Zakaria Aulia Rahman, Furqan Hidayatullah, Anthony Chi-Fai Ng   +3 more
doaj   +1 more source

Metabolism of soluble proteins by rumen microorganisms and the influence of condensed tannins on nitrogen solubility and degradation [PDF]

, 2004
The amino acid requirements of ruminants are met by two sources; microbes leaving the rumen and dietary protein escaping fermentation in the rumen. Much ruminant research has therefore focused on improving amino acid supply to the duodenum by increasing ...
Hedqvist, Helena
core  

In vitro immunological techniques in fascioliasis

, 1975
Experiments were conducted to examine ways of monitoring immunological responses in sheep to infection with Fasciola hepatica. The enzyme- linked immunosorbent assay (ELISA), the radioimmunoassay, and the agar gel precipitin technique were evaluated using the same somatic fluke antigen, for sensitivity and accuracy in the serodiagnosis of fascioliasis ...
openaire   +2 more sources

Cell Immortalization: In Vivo Molecular Bases and In Vitro Techniques for Obtention. [PDF]

BioTech (Basel), 2023
de Bardet JC, Cardentey CR, González BL, Patrone D, Mulet IL, Siniscalco D, Robinson-Agramonte MLA.   +6 more
europepmc   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

In Vitro Techniques and Measurements of Phage Characteristics That Are Important for Phage Therapy Success. [PDF]

Viruses, 2022
Glonti T, Pirnay JP.
europepmc   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

A feasible in vitro method to evaluate bacterial infiltration in three implant-abutment connection systems

Journal of Oral Research
Introduction: Microorganism infiltration through the im-plant-abutment interface causes oral health problems such as periimplantitis, leading to implant loss. Materials and Methods: A feasible new method to quantify the Streptococcus mutans (S.
Alexandre Cavalcante de Queiroz, Ivana Barbosa Suffredini, José Dimas de Oliveira, Jefferson de Souza Silva, Eduardo Fernandes Bondan   +4 more
doaj   +1 more source

Evaluating the potential of lignosulfonates and chitosans as alfalfa hay preservatives using in vitro techniques. [PDF]

J Anim Sci, 2022
Leon-Tinoco AY, Annis SL, Almeida ST, Guimarães BC, Killerby M, Zhang J, Wu C, Perkins LB, Ma Z, Jeong KC, Romero JJ.   +10 more
europepmc   +1 more source