Results 131 to 140 of about 2,462,763 (267)

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

FEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake, Yuki Enoki, Yuka Nakazawa, Kazuaki Taguchi, Kazuaki Matsumoto   +4 more
wiley   +1 more source

Author Correction: In vivo marker of brainstem myelin is associated to quantitative sleep parameters in healthy young men

Scientific Reports
Puneet Talwar, Michele Deantoni, Maxime Van Egroo, Vincenzo Muto, Daphne Chylinski, Ekaterina Koshmanova, Mathieu Jaspar, Christelle Meyer, Christian Degueldre, Christian Berthomier, André Luxen, Eric Salmon, Fabienne Collette, D.-J. Dijk, Christina Schmidt, Christophe Phillips, Pierre Maquet, Siya Sherif, Gilles Vandewalle   +18 more
doaj   +1 more source

Translational pathology in drug discovery

Frontiers in Pharmacology
Snježana Čužić, Maja Antolić, Anja Ognjenović, Vuk Milutinović, Sonja Vidović Iviš, Ines Glojnarić, Martina Bosnar, Lidija Požgaj, Ema Prenc, Vesna Eraković Haber   +9 more
doaj   +1 more source

Astrocytic connexins in alcohol use disorder: mechanisms of neuroinflammation and therapeutic potential. [PDF]

Front Psychiatry
Imafidon E, Allan-Le E, Dzirasa K, Marshall SA, Derk J.   +4 more
europepmc   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

Preclinical Quantitative In Vivo MRI Assessment of Exogenous Surfactant Pulmonary Distribution After Clinically Relevant Intratracheal Delivery. [PDF]

NMR Biomed
Marfouk O, Gérard R, Kaouane G, Leclerc L, Pinaud N, Fayon M, Périnel-Ragey S, Pourchez J, De La Roque ED, Crémillieux Y.   +9 more
europepmc   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Early Developmental Neuronal Activity Impacts Oligodendrocyte Differentiation Through AMPA Receptors. [PDF]

Glia
Allen TE, Peet G, Gomez Wulschner LE, Oh WC, Macklin WB.   +4 more
europepmc   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source