Results 161 to 170 of about 7,607,147 (352)

A Theoretical Basis for a Biopharmaceutic Drug Classification: The Correlation of in Vitro Drug Product Dissolution and in Vivo Bioavailability

Pharmaceutical Research, 1995
G. Amidon, H. Lennernäs, V. Shah, J. Crison   +3 more
semanticscholar   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

In Vivo Activity of a Novel Anti-Methicillin-Resistant Staphylococcus aureus Cephalosporin, Ceftaroline, against Vancomycin-Susceptible and -Resistant Enterococcus faecalis Strains in a Rabbit Endocarditis Model: a Comparative Study with Linezolid and Vancomycin

, 2009
Cédric Jacqueline, J. Caillon, V. Le Mabecque, A.-F. Miegeville, Yigong Ge, Donald Biek, Éric Batard, G. Potel   +7 more
openalex   +2 more sources

Oridonin Suppresses Human Gastric Cancer Growth <i>in Vitro</i> and <i>in Vivo</i> <i>via</i> Inhibition of VEGF, Integrin β3, and PCNA

, 2020
Qiong Yang, Wengdong Ma, Kun Yu, Qi Zhang, Zai‐yuan Ye, Wenjie Xia, Shuguang Li   +6 more
openalex   +2 more sources

Postnatal human dental pulp stem cells (DPSCs) in vitro and in vivo.

Proceedings of the National Academy of Sciences of the United States of America, 2000
S. Gronthos, M. Mankani, J. Brahim, P. Robey, S. Shi   +4 more
semanticscholar   +1 more source

Downregulation of sST2, a decoy receptor for interleukin‐33, enhances subcutaneous tumor growth in murine pancreatic cancer cells

FEBS Open Bio, EarlyView.
Subcutaneous implantation of murine Panc02 pancreatic cancer cells depleted of sST2, a soluble decoy receptor for the proinflammatory interleukin‐33 (IL‐33), leads to a decreased number of GLUT4‐positive cancer‐associated adipocytes, reduced levels of the anti‐inflammatory molecule adiponectin, increased phosphorylation of IκBα, elevated Cxcl3 ...
Miho Akimoto, Nobuko Koshikawa, Takao Morinaga, Mimi Tamamori‐Adachi, Atsushi Takatori, Keizo Takenaga   +5 more
wiley   +1 more source

Sleep- and sleep deprivation-related changes of vertex auditory evoked potentials during the estrus cycle in female rats

Scientific Reports
The estrus cycle in female rodents has been shown to affect a variety of physiological functions. However, little is known about its presumably thorough effect on auditory processing during the sleep–wake cycle and sleep deprivation.
Attila Tóth, Máté Traub, Norbert Bencsik, László Détári, Tünde Hajnik, Arpád Dobolyi   +5 more
doaj   +1 more source

Alterations in NF-κB and RBP-Jκ by Arenavirus Infection of Macrophages In Vitro and In Vivo

, 2002
Susan M. Fennewald, John F. Aronson, L. Zhang, Norbert K. Herzog   +3 more
openalex   +1 more source

Imaging of hypoxia, oxygen consumption and recovery in vivo during ALA-photodynamic therapy using delayed fluorescence of Protoporphyrin IX

, 2020
Marek Scholz, Arthur F. Pétusseau, Jason R. Gunn, Michael Chapman, Brian W. Pogue   +4 more
openalex   +1 more source