Results 211 to 220 of about 7,607,147 (352)

Overexpression of CDT1 inhibits cell cycle progression at S phase by interacting with the mini‐chromosome maintenance complex and causes DNA damage

FEBS Open Bio, EarlyView.
CDT1 is an essential protein for DNA replication licensing that loads the MCM complex, the eukaryotic replicative DNA helicase, onto replication origins. Overexpression of CDT1 induces cell cycle arrest at the S phase. Here we showed CDT1 inhibits the progression of replication forks by interacting with the MCM complex, leading to the stalling and ...
Takashi Tsuyama, Nonoka Takayama, Rina Tanaka, Yuuki Arai, Yohko Yamaguchi, Yuko Nawata, Yutaro Azuma, Shusuke Tada   +7 more
wiley   +1 more source

Characterization of the anticancer effect of mebendazole and its interaction with standard cytotoxic drugs in patient tumor cells <i>ex vivo</i> and in an <i>in vivo</i> mouse model. [PDF]

Oncol Rep
Mansoori S, Blom K, Andersson C, Fryknäs M, Larsson R, Nygren P.   +5 more
europepmc   +1 more source

Association of heat shock protein 70 expression with rat myocardial cell damage during heat stress in vitro and in vivo

, 2015
H.B. Chen, X.C. Zhang, Yanfen Cheng, A. Abdelnasir, Shu Tang, Nicole Kemper, J. Hartung, Endong Bao   +7 more
openalex   +1 more source

Thrombolytic proteins profiling: High‐throughput activity, selectivity, and resistance assays

FEBS Open Bio, EarlyView.
We present optimized biochemical protocols for evaluating thrombolytic proteins, enabling rapid and robust screening of enzymatic activity, inhibition resistance, and fibrin affinity, stimulation, and selectivity. The outcome translates to key clinical indicators such as biological half‐life and bleeding risk. These assays streamline the development of
Martin Toul, Alan Strunga, Jiri Damborsky, Zbynek Prokop   +3 more
wiley   +1 more source

Brain dissection photogrammetry: a tool for studying human white matter connections integrating ex vivo and in vivo multimodal datasets. [PDF]

Nat Commun
Vavassori L, Rheault F, Nocerino E, Annicchiarico L, Corsini F, Zigiotto L, De Benedictis A, Barbareschi M, Rozzanigo U, Avesani P, Sarubbo S, Petit L.   +11 more
europepmc   +1 more source

PEPTIDE SYNTHESIS IN VIVO

, 1947
Felix Friedberg, Theodore Winnick, David M. Greenberg   +2 more
openalex   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Day/night variations of myeloid and lymphoid cell subsets in the murine inguinal lymph node

FEBS Open Bio, EarlyView.
The circadian system is involved in the temporal regulation of the immune system. Our study reveals that two innate immune populations, NKT cells and neutrophils, predominate at the beginning of the day in healthy mice, highlighting how the time of day influences immune responses.
Paula M. Wagner, César G. Prucca, Lucia Boffelli, Virginia A. Piqueras, Silvia G. Correa, Mariana Maccioni, Mario E. Guido   +6 more
wiley   +1 more source

Intravital Microscopy of Osteocytes: A New Era in Bone Cell Biology. [PDF]

Curr Osteoporos Rep
Wasi M, Lewis KJ.
europepmc   +1 more source

RE: LESSONS LEARNED FROM LASER TISSUE SOLDERING AND FIBRIN GLUE PYELOPLASTY IN AN IN VIVO PORCINE MODEL

, 2001
C. G. Eden
openalex   +1 more source