Results 131 to 140 of about 15,871 (231)

Advances in Human Mass Balance Studies: An IQ Consortium Perspective on Current Practices and Emerging Trends

Clinical Pharmacology &Therapeutics, Volume 120, Issue 1, Page 43-54, July 2026.
Human radiolabeled mass balance studies are crucial for comprehensively characterizing the absorption, distribution, metabolism, and excretion (ADME) of investigational drugs, providing essential data for drug development, regulatory evaluation, and product labeling.
Jason Boer, Ellen Cannady, Filip Cuyckens, Ulrike Glaenzel, Camille Granvil, Felix Huth, Alexander D. James, Wenying Li, Céline Veau, Graeme Young, Qin Yue, Gregory S. Walker, Upendra A. Argikar, Jonathan N. Bauman, Cathy Cantalloube, Yu‐Luan Chen, Ping Kang, Patricia Moliner, Mette L. Pedersen, Isabel Piel, Simone Schadt, Hanno Schieferstein, Julia Suchomel, Shuai Wang, S. Cyrus Khojasteh   +24 more
wiley   +1 more source

The Development and Evaluation of Novel Reagents for Pre-Targeted Radioimmunotherapy [PDF]

, 2004
PhDIn a pretargeting radioimmunotherapy system, monoclonal antibodies (MAbs) derivatised with a high affinity streptavidin receptor are used in a localisation step.
Hainsworth, James Edward Scott
core  

Selective de-implementation of routine in vivo dosimetry. [PDF]

J Appl Clin Med Phys, 2023
Mao SPH, Han-Oh S, Moore J, Huang E, McNutt TR, Souranis AN, Briner V, Halthore A, Alcorn SR, Meyer JJ, Viswanathan AN, Wright JL.   +11 more
europepmc   +1 more source

High Throughput In vivo Imaging; A Pipeline for Automated Analysis of Longitudinal Preclinical Studies

Current Protocols, Volume 6, Issue 7, July 2026.
Abstract Fast acquisition times, multi‐animal beds, and improved accessibility of preclinical imaging systems have enabled high‐throughput imaging, significantly accelerating in vivo experimentation. However, image analysis remains largely manual, labor‐intensive, and inefficient, with significant inter‐ and intra‐user variability, adding to the ...
Mark Tchinov, Zachary Gurberg, Diana Möckel, Stefanie Rosenhain, Joseph Marsilio, Sarah Schraven, Kendahl Ott, Aaron LeBeau, Randall J. Kimple, Felix Gremse   +9 more
wiley   +1 more source

Development and characterization of a novel, small animal external beam irradiator using a clinical high dose rate brachytherapy source

Medical Physics, Volume 53, Issue 7, July 2026.
Abstract Background Pre‐clinical in vivo characterization is a necessary step in the translation of novel radiotherapeutic interventions to clinical application. In vivo irradiations using a radioactive source like Ir‐192 are challenging due to steep dose gradients and absence of universally available applicators that do not require physical contact or
Daniel Cecchi, Sacha Freeman, Greg Warren, Brad Gill, Chris Johnstone, Devika B. Chithrani, Samantha A. M. Lloyd   +6 more
wiley   +1 more source

Development and evaluation of an in vivo dose‐based monitoring system for electron FLASH radiation therapy

Medical Physics, Volume 53, Issue 7, July 2026.
Abstract Background FLASH radiotherapy requires further preclinical and clinical investigation to establish its biological effectiveness and define optimal beam parameters. In conventional (CONV) radiotherapy, redundant beam termination systems are a cornerstone ensuring patient safety, yet analogous safeguards for FLASH delivery are not well ...
Justin DeFrancisco, Matthew Richeson, Tomaj Javidtash, Chris Bartee, Tianjun Ma, Siyong Kim   +5 more
wiley   +1 more source

Catching errors with in vivo EPID dosimetry. [PDF]

, 2010
The potential for detrimental incidents and the ever increasing complexity of patient treatments emphasize the need for accurate dosimetric verification in radiotherapy.
Tielenburg, R, Mijnheer, B, Wendling, M, Stroom, J C, Sonke, J J, van Herk, M, Mans, A, Van Herk, Marcel; id_orcid, Vijlbrief, R, McDermott, L N   +9 more
core  

A scintillation dosimeter with real-time positional tracking information for in vivo dosimetry error detection in HDR brachytherapy. [PDF]

J Appl Clin Med Phys, 2023
Tho D, Lavallée MC, Beaulieu L.
europepmc   +1 more source

Acute Inhalation Exposure to Ultrafine Carbon Black Alters Mitochondrial Substrate Utilization in the Heart

Environmental Toxicology, Volume 41, Issue 7, Page 395-406, July 2026.
ABSTRACT A majority of deaths associated with air pollution are attributed to cardiovascular and heart diseases. Carbon black that represents the carbon core of particulate matter, a major component of air pollution, has been shown to result in cardiac mitochondrial dysfunction.
William E. Mullen, Jackson E. Stewart, Rahatul Islam, Salik Hussain, Dharendra Thapa   +4 more
wiley   +1 more source

Towards quantitative in vivo dosimetry using x-ray acoustic computed tomography. [PDF]

Med Phys, 2023
Sun L, Gonzalez G, Pandey PK, Wang S, Kim K, Limoli C, Chen Y, Xiang L.   +7 more
europepmc   +1 more source