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Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Isolated rapid eye movement sleep behavior disorder (iRBD) is a prodromal state for Lewy body disorders and exhibits biological heterogeneity that may influence clinical expression and progression. We examined clinical features in individuals with iRBD and biomarker‐defined synucleinopathy.
Daniel Weintraub +24 more
wiley +1 more source
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ACS Chemical Neuroscience, 2021
The combination of newly available genome sequence information on locusts together with high throughput genomics capabilities, novel approaches for genetic traceability, and their large size for easier handling makes locusts a valuable in vivo tool to study brain formation, functional adaptations, and neuropathogenesis during embryonic development in ...
Ruqaiyyah Siddiqui +2 more
openaire +2 more sources
The combination of newly available genome sequence information on locusts together with high throughput genomics capabilities, novel approaches for genetic traceability, and their large size for easier handling makes locusts a valuable in vivo tool to study brain formation, functional adaptations, and neuropathogenesis during embryonic development in ...
Ruqaiyyah Siddiqui +2 more
openaire +2 more sources
An in vivo model of functional and vascularized human brain organoids
Nature Biotechnology, 2018Differentiation of human pluripotent stem cells to small brain-like structures known as brain organoids offers an unprecedented opportunity to model human brain development and disease.
A. Mansour +10 more
semanticscholar +1 more source
Brain, behavior, and immunity, 2019
Parkinson's disease (PD) is a progressive, disabling neurodegenerative disorder. It has been shown Toll like receptor (TLR) 4-deficient mice protect against MPTP toxicity, suggesting that dopaminergic cell death is TLR4-dependent.
M. Campolo +5 more
semanticscholar +1 more source
Parkinson's disease (PD) is a progressive, disabling neurodegenerative disorder. It has been shown Toll like receptor (TLR) 4-deficient mice protect against MPTP toxicity, suggesting that dopaminergic cell death is TLR4-dependent.
M. Campolo +5 more
semanticscholar +1 more source
Modeling of Insulin Action In Vivo
Annual Review of Physiology, 1992The regulation of the level of glucose in blood is one of the most finely-tuned of the homeostatic mechanisms of the body. In normal individuals, the fasting glucose level varies little from day-to-day, despite wide swings in the intake of fuel and wide variations in energy output. It is reasonable to suppose that the precise regulation that we observe
R N, Bergman +3 more
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In Vivo Angiogenesis and Lymphangiogenesis Models
Current Molecular Medicine, 2009Angiogenesis research has become one of the most important areas in biomedical research. At the time of writing this review, there were approximately 3536 articles published in the year of 2008 alone on the topic of angiogenesis. The fast expansion of this research field demands development of rigorous, reliable, stable, convenient, and clinically ...
L D, Jensen, R, Cao, Y, Cao
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IN VIVO MODELS OF INTERSTITIAL CYSTITIS
Journal of Urology, 2002We systematically identified and evaluated various animal models that have been studied to help identify the underlying mechanisms of and possible treatment options for interstitial cystitis.Models of interstitial cystitis published between 1983 and 2001 were obtained by searching MEDLINE and other Internet databases using cystitis and model as the ...
Jodi L, Westropp, C A Tony, Buffington
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In Vivo Experimental Models of Epilepsy
Central Nervous System Agents in Medicinal Chemistry, 2010This study reviews the different in vivo experimental models that have been used for the study of epileptogenesis. In this review we will focus on how to replicate the different models that have led to the study of partial seizures, as well as generalized seizures and the status epilepticus.
Carmen Rubio +5 more
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Androgenetic Alopecia: In Vivo Models
Experimental and Molecular Pathology, 1999Androgenetic alopecia is the most common form of balding in humans. There is great interest in finding a reliable animal model to study the pathogenesis and treatment of this abnormality. The sump-tailed macaque (Macaca artoides) has been the standard model and appears to be useful homologue.
Sundberg, J P +4 more
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