Results 211 to 220 of about 681,576 (264)

In Vivo Models of Rheumatoid Arthritis

2019
Rheumatoid arthritis (RA) models in mice induced by immunization enable the analyses of molecular mechanism involved in disease development, progression, and resolution of inflammation. Here, we describe three different models mimicking clinic symptoms of human rheumatoid arthritis, which could be transferable to any genetically modified mouse. We will
Bettina, Grötsch, Aline, Bozec, Georg, Schett   +2 more
openaire   +2 more sources

An in vivo model of human small intestine using pluripotent stem cells

Nature Medicine, 2014
Differentiation of human pluripotent stem cells (hPSCs) into organ-specific subtypes offers an exciting avenue for the study of embryonic development and disease processes, for pharmacologic studies and as a potential resource for therapeutic transplant.
Carey L. Watson, Maxime M. Mahe, J. Múnera, J. Howell, Nambirajan Sundaram, H. Poling, Jamie I. Schweitzer, Jefferson E. Vallance, C. Mayhew, Ying Sun, G. Grabowski, Stacy R. Finkbeiner, J. Spence, N. Shroyer, James M. Wells, M. Helmrath   +15 more
semanticscholar   +1 more source

In Vivo Models of Mechanical Loading

2019
The skeleton fulfils its mechanical functions through structural organization and material properties of individual bones. It is stated that both cortical and trabecular morphology and mass can be (re)modelled in response to changes in mechanical strains engendered by load-bearing.
Javaheri, Behzad, Bravenboer, Nathalie, Bakker, Astrid D., van der Veen, Albert, de Souza, Roberto Lopes, Saxon, Leanne, Pitsillides, Andrew A.   +6 more
openaire   +3 more sources

Chemopreventive effect of quercetin, a natural dietary flavonoid on prostate cancer in in vivo model.

Clinical Nutrition, 2014
BACKGROUND & AIM Prostate cancer is one of the frequently diagnosed cancers in men. Increased Growth factor IGF-1/IGF-1R axis activation mediated by both PI3K/Akt or RAF/MEK/ERK system and AR expression remains important in the development and ...
G. Sharmila, F. Bhat, R. Arunkumar, P. Elumalai, Paulraj Raja Singh, K. Senthilkumar, J. Arunakaran   +6 more
semanticscholar   +1 more source

In Vivo Models for Inflammatory Arthritis

2018
In vivo mouse models of inflammatory arthritis are extensively used to investigate pathogenic mechanisms governing inflammation-driven joint damage. Two commonly utilized models include collagen-induced arthritis (CIA) and methylated bovine serum albumin (mBSA) antigen-induced arthritis (AIA).
Jones, Gareth, Hill, David, Sime, Katie, Williams, Anwen   +3 more
openaire   +3 more sources

Xenograft as In Vivo Experimental Model

2017
The identification of experimental models that recapitulate human cancers designed to predict patient clinical response to therapies is a major break in oncology. Cancer stem cells (CSCs) represent a small tumor cell population responsible for drug resistance, where their effective killing may lead to identifying better treatment options.
Manuela, Porru, Luca, Pompili, Carla, Caruso, Carlo, Leonetti   +3 more
openaire   +2 more sources

An experimental model of in vivo fibrinolysis

Thrombosis Research, 1976
Abstract An experimental model of in vivo fibrinolysis was devised for estimation of in vivo fibrinolytic activity in experimental animals (rat, rabbit and dog). The method consists of intravenous injection of homogenized human fibrin into an animal and subsequent immunological determination of fibrin degradation products (FDP) in a small
Y, Sasaki, T, Morita
openaire   +2 more sources

In vivo models in the study of osteopenias.

European journal of clinical chemistry and clinical biochemistry : journal of the Forum of European Clinical Chemistry Societies, 1991
A better insight into bone pathophysiology is required for a full understanding of the mechanisms leading to bone loss in humans. Animal models of bone disease appear to be the most valuable for this purpose. Certain differences in bone metabolism exist between various species.
Češnjaj, Mirjana, Stavljenić, Ana, Vukičević, Slobodan   +2 more
openaire   +3 more sources

In Vivo Rat Model of Preeclampsia

2006
Preeclampsia is characterized by the clinical triad of new hypertension, proteinuria, and edema after 20 wk of gestation. Recent evidence suggests that disturbances in angiogenic factors (such as vascular endothelial growth factor and placental growth factor) signaling and endothelial health may play a major role in the pathogenesis of preeclampsia ...
S Ananth, Karumanchi, Isaac E, Stillman
openaire   +2 more sources

Zebrafish as a preclinical in vivo screening model for nanomedicines.

Advanced Drug Delivery Reviews, 2019
The interactions of nanomedicines with biological environments is heavily influenced by their physicochemical properties. Formulation design and optimization are therefore key steps towards successful nanomedicine development.
S. Sieber, Philip Grossen, J. Bussmann, Frederick Campbell, A. Kros, D. Witzigmann, J. Huwyler   +6 more
semanticscholar   +1 more source