Results 271 to 280 of about 2,991,035 (302)
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In Vivo Models of Mechanical Loading
The skeleton fulfills its mechanical functions through structural organization and material properties of individual bones. It is stated that both cortical and trabecular morphology and mass can be (re)modeled in response to changes in mechanical strains engendered by load-bearing.Dionysia, Valkani +2 more
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Generating an Ex Vivo Vascular Model
ASAIO Journal, 2005Realistic ex vivo anthropometric vascular environments are required for endovascular device optimization and for preclinical evaluation of interventional procedures. The objective of this research is to build an anthropomorphic model of the human carotid artery.
O??Flynn, Padraig M. +2 more
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In Vitro and In Vivo Models of Multiple Sclerosis
CNS & Neurological Disorders - Drug Targets, 2012Multiple sclerosis (MS) is widely considered to be the result of an aggressive autoreactive T cell attack on myelin. How these autoimmune responses arise in MS is unclear, but they could result from virus infections. Thus, viral and autoimmune diseases in animals have been used to investigate the possible pathogenic mechanisms operating in MS.
van der Star, B.J. +5 more
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Predictive In Vivo Models for Oncology
2015Experimental oncology research and preclinical drug development both substantially require specific, clinically relevant in vitro and in vivo tumor models. The increasing knowledge about the heterogeneity of cancer requested a substantial restructuring of the test systems for the different stages of development.
Diana, Behrens +2 more
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An In Vivo Model of Recurrent Glioblastoma
Glioblastoma (GBM) is a highly aggressive and prevalent adult brain tumor. Despite an intensive standard of care consisting of surgical resection followed by radiation therapy and chemotherapy with temozolomide, patients invariably succumb to the recurrent tumor and face an overall survival of less than 15 months.Muhammad Vaseem, Shaikh +4 more
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An in vivo neuroimmune organoid model to study human microglia phenotypes
Cell, 2023Abed AlFatah Mansour +2 more
exaly
In Vivo Models of Hypercalcemia of Malignancy
1994For about 30 years there has been interest in animal models of hypercalcemia of malignancy (HHM), which affects not only humans but also animals. Dogs for example spontaneously develop hypercalcemia with malignant diseases such as lymphosarcoma (Weiler and Melcon 1978; Heath et al. 1980) and adenocarcinoma (Patnaik et al. 1978).
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In vivo cancer modeling using mouse models
Mouse models have contributed to a better understanding of cancer biology and the development of new treatments. This chapter elaborates on the various types of mouse models applied in cancer research, such as xenograft, syngeneic, and humanized models, together with the state-of-the-art techniques of genetic engineering involved in their generation ...Prafulla Chandra, Tiwari +3 more
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