Results 71 to 80 of about 118,707,215 (312)

Anxiolytic Efficacy of Indirubin: In Vivo Approach Along with Receptor Binding Profiling and Molecular Interaction with GABAergic Pathways

ChemistryOpen
Anxiety is a natural response to stress, characterized by feelings of worry, fear, or unease. The current research was conducted to investigate the anxiolytic effect of indirubin (IND) in different behavioral paradigms in Swiss albino mice.
Ishrat Jahan Disha, Rubel Hasan, Md. Shimul Bhuia, Siddique Akber Ansari, Irfan Aamer Ansari, Muhammad Torequl Islam   +5 more
doaj   +1 more source

Oxandrolone treatment prevents muscle atrophy and retraction after rotator cuff injury: an experimental study in rats

JSES Reviews, Reports, and Techniques
Background: Chronic rotator cuff (RC) tear leads to muscle atrophy, fatty infiltration, and intercellular fibrosis of the torn muscle-tendon unit. Prevention of muscle degeneration appears desirable to allow further treatment options to be successful ...
Polychronis Papadopoulos, MD, Cangyu Wang, MD, MS, Felix H. Savoie, III, MD, Zongbing You, MD, PhD, Dongxia Ge, MD, PhD   +4 more
doaj   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Ligandi dei siti recettoriali orto- e allosterici: caratterizzazione in vitro e in vivo di nuovi derivati dualsterici bisammonioalcanici

, 2015
In this study we characterized in vitro and in vivo three different groups of dualsteric compounds, which were synthesized as M2 muscarinic agonists. These bitopic ligands, which incorporate in a unique molecule an orthosteric muscarinic agonist and a ...
VIVO, Valentina
core  

vivo-project/VIVO: Release vivo-1.14.1

<p><strong>Release vivo 1.14.1</strong><br/>It is recommended that you review the 1.14 Documentation and the VIVO/Vitro READMEs on github before you start.<br/>If you are new to VIVO/Vitro it is suggested that you take ...
Jim Blake, Stefan-Wolff, Brian Caruso, Andrew Woods, Nate Prewitt, William Welling, Don Elsborg, hudajkhan, Ralph O'Flinn, Georgy Litvinov, Alex Viggio, tworrall, Ben, Ted Lawless, Miloš Popović, Arfon Smith, vivo-uab, Jon Corson-Rikert, Steve McKay, Mike Conlon, Dragan Ivanovic, hauschke, Brian Lowe, Stephen V. Williams, Holly Mistlebauer, Michel Héon, Laura Wrubel, Graham Triggs   +27 more
core   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

A Correlative Imaging Study of in vivo and ex vivo Biodistribution of Solid Lipid Nanoparticles

International Journal of Nanomedicine, 2020
Silvia Mannucci,1 Federico Boschi,2,* Barbara Cisterna,1,* Elisabetta Esposito,3 Rita Cortesi,3 Claudio Nastruzzi,3 Enrica Cappellozza,1 Paolo Bernardi,1 Andrea Sbarbati,1 Manuela Malatesta,1 Laura Calderan1 1Department of Neurosciences, Biomedicine and ...
Mannucci S, Boschi F, Cisterna B, Esposito E, Cortesi R, Nastruzzi C, Cappellozza E, Bernardi P, Sbarbati A, Malatesta M, Calderan L   +10 more
doaj  

Toxicity of Crepis lacera in grazing ruminants

BMC Veterinary Research, 2018
Background Crepis lacera is a plant from the Asteraceae family that is common in the Mediterranean region. Farmers believe that this plant may be deadly to small ruminants in areas of southern Italy.
Rosario Russo, Brunella Restucci, Antonio Vassallo, Laura Cortese, Massimiliano D’Ambola, Serena Montagnaro, Roberto Ciarcia, Salvatore Florio, Nunziatina De Tommasi, Lorella Severino   +9 more
doaj   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source