Results 61 to 70 of about 118,707,215 (312)

Blue-green partnership: unravelling potential of marine Pseudomonas aeruginosa OG as a biocontrol agent against Fusarium oxysporum vasinfectum

Discover Oceans
Cotton, a crop of significant economic importance in India, is confronted with a multitude of soil-borne illnesses. Fusarium wilt, caused by the pathogen Fusarium oxysporum f. sp. vasinfectum (FOV).
Janki N. Thakker, Khushbu Rathod, Keyur Patel, Jenali Pandya, Jinal Badrakia, Pinakin Dhandhukia   +5 more
doaj   +1 more source

Design, characterization, and evaluation of an aceclofenac cocrystal for improved solubility and stability

Journal of Applied Pharmaceutical Research
Background: Co-crystallization enhances APIs by forming noncovalent interactions with coformers, thereby improving physicochemical properties. Aceclofenac was selected for its low solubility, whereas L-lysine serves as a coformer to enhance solubility ...
Aditay Kumar, Mahesh Kumar
doaj   +1 more source

Data on combination effect of PEG-coated gold nanoparticles and non-thermal plasma inhibit growth of solid tumors

Data in Brief, 2016
Highly resistant tumor cells are hard to treat at low doses of plasma. Therefore, researchers have gained more attention to development of enhancers for plasma therapy.
Nagendra Kumar Kaushik, Neha Kaushik, Ki Chun Yoo, Nizam Uddin, Ju Sung Kim, Su Jae Lee, Eun Ha Choi   +6 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

On Butler $B(2)$-groups decomposing over two base elements [PDF]

, 2009
summary:A $B(2)$-group is a sum of a finite number of torsionfree Abelian groups of rank $1$, subject to two independent linear relations. We complete here the study of direct decompositions over two base elements, determining the cases where the ...
Metelli, Claudia, De Vivo, Clorinda
core   +1 more source