Results 41 to 50 of about 2,222,057 (269)

Determination of analgesic potential of Helicteres isora and molecular involvement of opioids and GABA receptors

Phytomedicine Plus
Herbal medicines are used as a source of therapeutic agents as they are safer and less toxic than synthetic drugs. Several species of Helicteres isora (Sterculiaceae) have been documented in folk medicine to have analgesic properties. This study is aimed
Fakhria A. Al-Joufi, Hayat Bilal, Mubarak Ali Khan, Syed Muhammad Tahir Shah, Syed Muhammad Mukarram Shah, Muhammad Zahoor, Syed Wadood Ali Shah   +6 more
doaj   +1 more source

Morphofunctional Characteristics of the Hippocampus of White Rats in the Acute Period After Severe Traumatic Brain Injury During the Use of L-lysine Aescinat

Неотложная медицинская помощь, 2021
Aim of study. The study is devoted to the effect of L-lysine aescinat on the nervous tissue of the CA1 and CA3 fields of the hippocampus of the brain of white rats in the acute period after severe traumatic brain injury (TBI).Material and methods.
I. P. Koshman, A. Yu. Shoronova, S. S. Stepanov, A. G. Kalinichev, V. A. Akulinin, A. S. Stepanov, D. B. Avdeyev, V. L. Molchanova   +7 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Botanical Flavonoids: Efficacy, Absorption, Metabolism and Advanced Pharmaceutical Technology for Improving Bioavailability

Molecules
Flavonoids represent a class of natural plant secondary metabolites with multiple activities including antioxidant, antitumor, anti-inflammatory, and antimicrobial properties.
Lei Hu, Yiqing Luo, Jiaxin Yang, Chunsong Cheng   +3 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Use and reporting of historical control data for regulatory studies

EFSA Journal
The provision of historical control data (HCD) is a data requirement for pesticide active substances established by European legislation. HCD are data from studies conducted under the same or similar conditions as the toxicity study under assessment ...
EFSA Panel on Plant Protection Products and their Residues (PPR), Tamara Coja, Pauline Adriaanse, Judy Choi, Antonio Finizio, Maeva Giraudo, Thomas Kuhl, Francesca Metruccio, Martin Paparella, Silvia Pieper, Eugenio Scanziani, Ivana Teodorovic, Paul Van der Brink, Peter Craig, Bertrand Desprez, Ian Dewhurst, Emily McVey, Arianna Chiusolo, Anna Lanzoni, Sara Levorato, Laura Martino, Tommaso Giorgi, Martin Wilks   +22 more
doaj   +1 more source

Antiplasmodial and in vitro antioxidant potentials of crude aqueous and methanol extracts of Chasmanthera dependens (Hochst)

Bulletin of the National Research Centre, 2022
Background Malaria is a major cause of death in tropical countries such as Nigeria. Chasmanthera dependens (Hochst) is a wild plant used by traditional healers for the treatment of malaria and other health challenges.
Conrad Kenechukwu Enenebeaku, Cynthia Ekwy Ogukwe, Christian Okechukwu Nweke, Sylvia Onyinyechi Anyado-Nwadike, Martin Obi, Ijeoma Akunna Duru, Uchechi Emmanuela Enenebeaku, Odangowei I. Ogidi   +7 more
doaj   +1 more source

In Vivo Antihypertensive and Ex Vivo Vasodilatory Studies of Taxifolin

Pharmaceuticals
Background: Hypertension is a leading cause of cardiovascular morbidity and mortality. Taxifolin has shown cardiovascular benefits, but its antihypertensive mechanisms remain poorly defined. This study aimed to comprehensively elucidate the molecular mechanisms underlying Taxifolin’s blood pressure-lowering effects by integrating network pharmacology ...
Xuye Wang, Xiangyang Xu, Wan Yin Tew, Liyun Ouyang, Xiaoning Yang, Hui Wei Loh, Wen Xu, Wei Xu, Mun Fei Yam   +8 more
openaire   +3 more sources

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Oil-based and oil-free formulations for enhancing cannabidiol bioavailability

Journal of Cannabis Research
Background Cannabidiol (CBD) exhibits therapeutic potential due to its analgesic, anxiolytic, anti-inflammatory, and anticonvulsant effects. However, its oral bioavailability is limited by poor water solubility and extensive first-pass metabolism ...
Petr Jelínek, Anežka Klouček, Ashley Hannah George, Hynek Housar, Petr Kozlík, Tomáš Křížek, Pavel Ryšánek, Martin Šíma, Ondřej Slanař, Miroslav Šoóš   +9 more
doaj   +1 more source