Results 51 to 60 of about 118,707,215 (312)

Microencapsulated Chitosan-Based Nanocapsules: A New Platform for Pulmonary Gene Delivery

Pharmaceutics, 2021
In this work, we propose chitosan (CS)-based nanocapsules (NCs) for pulmonary gene delivery. Hyaluronic acid (HA) was incorporated in the NCs composition (HA/CS NCs) aiming to promote gene transfection in the lung epithelium. NCs were loaded with a model
Estefanía Fernández-Paz, Lucía Feijoo-Siota, Maria Manuela Gaspar, Noemi Csaba, Carmen Remuñán-López   +4 more
doaj   +1 more source

In Vivo Antihypertensive and Ex Vivo Vasodilatory Studies of Taxifolin

Pharmaceuticals
Background: Hypertension is a leading cause of cardiovascular morbidity and mortality. Taxifolin has shown cardiovascular benefits, but its antihypertensive mechanisms remain poorly defined. This study aimed to comprehensively elucidate the molecular mechanisms underlying Taxifolin’s blood pressure-lowering effects by integrating network pharmacology ...
Xuye Wang, Xiangyang Xu, Wan Yin Tew, Liyun Ouyang, Xiaoning Yang, Hui Wei Loh, Wen Xu, Wei Xu, Mun Fei Yam   +8 more
openaire   +3 more sources

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Use and reporting of historical control data for regulatory studies

EFSA Journal
The provision of historical control data (HCD) is a data requirement for pesticide active substances established by European legislation. HCD are data from studies conducted under the same or similar conditions as the toxicity study under assessment ...
EFSA Panel on Plant Protection Products and their Residues (PPR), Tamara Coja, Pauline Adriaanse, Judy Choi, Antonio Finizio, Maeva Giraudo, Thomas Kuhl, Francesca Metruccio, Martin Paparella, Silvia Pieper, Eugenio Scanziani, Ivana Teodorovic, Paul Van der Brink, Peter Craig, Bertrand Desprez, Ian Dewhurst, Emily McVey, Arianna Chiusolo, Anna Lanzoni, Sara Levorato, Laura Martino, Tommaso Giorgi, Martin Wilks   +22 more
doaj   +1 more source

Comparison of Wear of Interim Crowns in Accordance with the Build Angle of Digital Light Processing 3D Printing: A Preliminary In Vivo Study

Bioengineering, 2022
The aim of this study is to evaluate the wear volume of interim crowns fabricated using digital light processing 3D printing according to the printing angle. A total of five patients undergoing the placement of a single crown on the mandibular molar were
Hakjun Lee, Keunbada Son, Du-Hyeong Lee, So-Yeun Kim, Kyu-Bok Lee   +4 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

IN VIVO STUDY OF THE SV2A PROTEIN IN AN EPILEPTIC RAT MODEL [PDF]

, 2017
Introduction Epilepsy is one of the commonest neurological disorders, affecting more than 60 million people worldwide [1]. New and effective antiepileptic drugs mainly target the SV2A protein [2] but its actual role is still largely unknown.
Lemaire, Christian, Salmon, Eric, Aerts, Joël, Warnier, Corentin, Plenevaux, Alain, Becker, Guillaume, Luxen, André, Serrano Navacerrada, Maria Elisa, Giacomelli, Fabrice, Mievis, Frédéric, Bahri, Mohamed Ali   +10 more
core  

Oil-based and oil-free formulations for enhancing cannabidiol bioavailability

Journal of Cannabis Research
Background Cannabidiol (CBD) exhibits therapeutic potential due to its analgesic, anxiolytic, anti-inflammatory, and anticonvulsant effects. However, its oral bioavailability is limited by poor water solubility and extensive first-pass metabolism ...
Petr Jelínek, Anežka Klouček, Ashley Hannah George, Hynek Housar, Petr Kozlík, Tomáš Křížek, Pavel Ryšánek, Martin Šíma, Ondřej Slanař, Miroslav Šoóš   +9 more
doaj   +1 more source

Doxorubicin Conjugated to Glutathione Stabilized Gold Nanoparticles (Au-GSH-Dox) as an Effective Therapeutic Agent for Feline Injection-Site Sarcomas—Chick Embryo Chorioallantoic Membrane Study

Molecules, 2017
Feline injection-site sarcomas are malignant skin tumours with a high local recurrence rate, ranging from 14% to 28%. The treatment of feline injection-site sarcomas includes radical surgery, radiotherapy and/or chemotherapy. In our previous study it has
Katarzyna Zabielska-Koczywąs, Izabella Dolka, Magdalena Król, Artur Żbikowski, Wiktor Lewandowski, Józef Mieczkowski, Michał Wójcik, Roman Lechowski   +7 more
doaj   +1 more source

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source