Results 31 to 40 of about 2,568,108 (218)

Local estradiol deposition in a rat rotator cuff repair model: proof of concept

JSES International
Background: Local delivery of hormones could potentially provide local benefits to bone and enthesis while avoiding systemic side effects. The objective of this study was to demonstrate proof of concept for local deposition of estradiol in a rat rotator ...
Peter N. Chalmers, MD, Michael J. Jurynec, PhD, Austin M. Hickey, MS, T. Wade Fallin, MS, Antonio C. Zelada, BS, Matthew Honeggar, BS, James M. Hotaling, MD, Benjamin Emery, MPhil, Robert Tashjian, MD   +8 more
doaj   +1 more source

In vivo Modulatory Effect of Coffee (Coffea canephora var. Robusta) on the Expression Levels of Murine microRNA-124-3p Associated with Antioxidant Defenses

eFood, 2019
Antioxidant activity is one of the most studied properties of coffee as a beverage, and is mainly ascribed to its polyphenol content, although there is limited scientific literature regarding its mechanism of action at the molecular level.
Valeria Curti, Manuela Verri, Alessandra Baldi, Marco Dacrema, Irene Masiello, Maurizia Dossena, Maria Daglia   +6 more
doaj   +1 more source

Design, synthesis and cytotoxic evaluation of novel bis-thiazole derivatives as preferential Pim1 kinase inhibitors with in vivo and in silico study

Journal of Enzyme Inhibition and Medicinal Chemistry, 2023
Bis-thiazole derivatives were synthesised conforming to the Pim1 pharmacophore model following Hantzsch condensation. Pim1 has a major role in regulating the G1/S phase which upon inhibition the cell cycle stops at its early stages. Derivatives 3b and 8b
Mohammad M. Al-Sanea, Tamer M. Nasr, Samir Bondock, Aya Y. Gawish, Nada M. Mohamed   +4 more
doaj   +1 more source

Hypoxia Studies with Pimonidazole in vivo [PDF]

BIO-PROTOCOL, 2014
Therapy-induced hypoxia drives changes in the tumor microenvironment that contribute to the poor response to therapy. Hypoxia is capable of driving the expression and/or activation of specific signaling cascades (e.g., c-Met, Axl, CTGF), the recruitment of tumor promoting immune cells, and the induction of cell survival pathways including autophagy ...
Kristina Aguilera, Rolf Brekken
openaire   +3 more sources

A System to Study Aneuploidy In Vivo [PDF]

Cold Spring Harbor Symposia on Quantitative Biology, 2015
Aneuploidy, an imbalanced chromosome number, is associated with both cancer and developmental disorders such as Down syndrome (DS). To determine how aneuploidy affects cellular and organismal physiology, we have developed a system to evaluate aneuploid cell fitness in vivo.
Pfau, Sarah Jeanne, Amon, Angelika B
openaire   +4 more sources

Bionate Biocompatibility: In Vivo Study in Rabbits

ACS Omega, 2022
Response to foreign materials includes local tissue reaction, osteolysis, implant loosening, and migration to lymph nodes and organs. Bionate 80A human explants show minor wear and slight local tissue reaction, but we do not know the response at the spinal cord, nerve roots, lymph nodes, or distant organs.
Amparo Vanaclocha-Saiz, Vicente Vanaclocha, Carlos Atienza, Pablo Jorda-Gomez, Víctor Primo-Capella, Carlos Barrios, Leyre Vanaclocha   +6 more
openaire   +5 more sources

From moths to caterpillars: Ideal conditions for Galleria mellonella rearing for in vivo microbiological studies

Virulence, 2018
Galleria mellonella is a well-accepted insect model for the study of pathogen-host interactions and antimicrobial compounds. The main advantages of this model include the low cost of maintenance, the fast life cycle, the possibility of using a large ...
Adeline L. Jorjão, Luciane D. Oliveira, Liliana Scorzoni, Lívia Mara A. Figueiredo-Godoi, Marcia Cristina A. Prata, Antonio Olavo C. Jorge, Juliana C. Junqueira   +6 more
doaj   +1 more source

In Vivo Degradation Behavior of the Magnesium Alloy LANd442 in Rabbit Tibiae [PDF]

, 2011
In former studies the magnesium alloy LAE442 showed promising in vivo degradation behavior and biocompatibility. However, reproducibility might be enhanced by replacement of the rare earth composition metal "E" by only a single rare earth element ...
Reifenrath, Janin, Ullmann, Berit, Dziuba, Dina, Seitz, Jan-Marten, Dirk Bormann, Andrea Meyer-Lindenberg, Bormann, Dirk, Dina Dziuba, Meyer-Lindenberg, Andrea, Berit Ullmann, Janin Reifenrath, Jan-Marten Seitz   +11 more
core   +1 more source

Therapeutic Potency of Mono and Diprenylated Acetophenone: A Case Study of in-vivo Antimalarial Evaluation

, 2022
Malaria remains a febrile infection of public health concern in many countries especially tropical countries in Africa, and certain countries in Southern and North America such as Brazil, Costa Rica, Mexico, Dominican Republic, Colombia, and Ecuador ...
Hayatudeen, Muhammad, Sodeeq, Babalola, Amina, Olorukooba, Nosa, Igie, Aliyu, Musa, Abdullah, Idris, Asmau, Hamza, Isaiah, Odeyemi   +7 more
core   +1 more source

Determination of analgesic potential of Helicteres isora and molecular involvement of opioids and GABA receptors

Phytomedicine Plus
Herbal medicines are used as a source of therapeutic agents as they are safer and less toxic than synthetic drugs. Several species of Helicteres isora (Sterculiaceae) have been documented in folk medicine to have analgesic properties. This study is aimed
Fakhria A. Al-Joufi, Hayat Bilal, Mubarak Ali Khan, Syed Muhammad Tahir Shah, Syed Muhammad Mukarram Shah, Muhammad Zahoor, Syed Wadood Ali Shah   +6 more
doaj   +1 more source