Results 31 to 40 of about 118,707,215 (312)

Formulation and Optimization of Repaglinide Nanoparticles Using Microfluidics for Enhanced Bioavailability and Management of Diabetes

Biomedicines, 2023
The technologies for fabrication of nanocrystals have an immense potential to improve solubility of a variety of the poor water-soluble drugs with subsequent enhanced bioavailability.
Mubashir Ahmad, Shahzeb Khan, Syed Muhammad Hassan Shah, Muhammad Zahoor, Zahid Hussain, Haya Hussain, Syed Wadood Ali Shah, Riaz Ullah, Amal Alotaibi   +8 more
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Safety assessment and in vitro cytotoxicity profiling of fruiting bodies from Lentinula edodes (shiitake) strains in HeLa and MCF-7 cell lines

Scientific Reports
Medicinal mushrooms offer diverse therapeutic benefits, but proper administration is crucial to avoid long-term health issues linked to fungal toxicity.
Sujata Makkar, Kiran Nehra, Ajay Singh, Sudheer Kumar Annepu   +3 more
doaj   +1 more source

Local estradiol deposition in a rat rotator cuff repair model: proof of concept

JSES International
Background: Local delivery of hormones could potentially provide local benefits to bone and enthesis while avoiding systemic side effects. The objective of this study was to demonstrate proof of concept for local deposition of estradiol in a rat rotator ...
Peter N. Chalmers, MD, Michael J. Jurynec, PhD, Austin M. Hickey, MS, T. Wade Fallin, MS, Antonio C. Zelada, BS, Matthew Honeggar, BS, James M. Hotaling, MD, Benjamin Emery, MPhil, Robert Tashjian, MD   +8 more
doaj   +1 more source

In vivo Modulatory Effect of Coffee (Coffea canephora var. Robusta) on the Expression Levels of Murine microRNA-124-3p Associated with Antioxidant Defenses

eFood, 2019
Antioxidant activity is one of the most studied properties of coffee as a beverage, and is mainly ascribed to its polyphenol content, although there is limited scientific literature regarding its mechanism of action at the molecular level.
Valeria Curti, Manuela Verri, Alessandra Baldi, Marco Dacrema, Irene Masiello, Maurizia Dossena, Maria Daglia   +6 more
doaj   +1 more source

Design, synthesis and cytotoxic evaluation of novel bis-thiazole derivatives as preferential Pim1 kinase inhibitors with in vivo and in silico study

Journal of Enzyme Inhibition and Medicinal Chemistry, 2023
Bis-thiazole derivatives were synthesised conforming to the Pim1 pharmacophore model following Hantzsch condensation. Pim1 has a major role in regulating the G1/S phase which upon inhibition the cell cycle stops at its early stages. Derivatives 3b and 8b
Mohammad M. Al-Sanea, Tamer M. Nasr, Samir Bondock, Aya Y. Gawish, Nada M. Mohamed   +4 more
doaj   +1 more source

Hypoxia Studies with Pimonidazole in vivo [PDF]

BIO-PROTOCOL, 2014
Therapy-induced hypoxia drives changes in the tumor microenvironment that contribute to the poor response to therapy. Hypoxia is capable of driving the expression and/or activation of specific signaling cascades (e.g., c-Met, Axl, CTGF), the recruitment of tumor promoting immune cells, and the induction of cell survival pathways including autophagy ...
Kristina Aguilera, Rolf Brekken
openaire   +3 more sources

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Research progress in biodegradable Zn-based materials for orthopedic applications

Cailiao gongcheng, 2022
In recent years, zinc alloys have shown great potential as orthopedic plant materials because of their excellent biocompatibility, osteoinductive and biodegradation activities in vivo.
SUN Jiang, SHI Zhangzhi, LI Yageng, LI Xiangmin, LI Weishi, WANG Luning   +5 more
doaj   +1 more source