Results 211 to 220 of about 163,771 (263)
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Pharmacokinetics of Drugs That Inactivate Metabolic Enzymes
Journal of Pharmaceutical Sciences, 1991The pharmacokinetics of drugs that cause inactivation of metabolic enzymes were derived for the single-compartment model with linear elimination kinetics. A simple mechanism for suicide inactivation of enzyme by its substrate was used to model the relationship between elimination of drug and enzyme activity as a function of time.
M R, Gray, Y K, Tam
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Neuropeptidases and the metabolic inactivation of insect neuropeptides
General and Comparative Endocrinology, 2009Neuropeptidases play a key role in regulating neuropeptide signalling activity in the central nervous system of animals. They are oligopeptidases that are generally found on the surface of neuronal cells facing the synaptic and peri-synaptic space and therefore are ideally placed for the metabolic inactivation of neuropeptide transmitters/modulators ...
Isaac, R. Elwyn +2 more
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Formate metabolism in the cobalamin‐inactivated rat
British Journal of Haematology, 1990SummaryEndogenous formate levels in blood and liver were assayed in rats both after inactivation of cobalamin (Cbl) by exposure to N2O as well as in air‐breathing controls. The uptake of [14C]formate by tetrahydrofolate (H4folate) in bone marrow cells and liver homogenate and the incorporation of [14C]formate into purine, pyrimidine, methionine, serine
R, Deacon +3 more
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Metabolic activation and inactivation of chemical carcinogens
Journal of Toxicology and Environmental Health, 1980Chemical carcinogens are metabolized by numerous pathways catalyzed by enzymes in endoplasmic reticulum and other parts of the cell. Reactions in which functional groups are created (epoxidation and epoxide hydration, catalyzed by cytochrome P-450-linked monooxygenase and epoxide hydratase, respectively) are especially important in the activation of ...
O, Pelkonen, K, Vähäkangas
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Inactivation of CYP2A6 and CYP2A13 during Nicotine Metabolism
The Journal of Pharmacology and Experimental Therapeutics, 2006Nicotine is the major addictive agent in tobacco. The primary catalyst of nicotine metabolism in humans is CYP2A6. However, the closely related enzyme CYP2A13 is a somewhat better catalyst. CYP2A13 is an extrahepatic enzyme that is an excellent catalyst of the metabolic activation of the tobacco-specific carcinogen 4-(methylnitrosamine)-1-(3-pyridyl)-1-
Linda B, von Weymarn +2 more
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Metabolic inactivation of bleomycin analogs by bleomycin hydrolase
Pharmacology & Therapeutics, 1988La bleomycine est inactivee in vivo et in vitro par une enzyme appelee bleomycine hydrolase, et transformee en deaminobleomycine a activite biologique reduite. Les caracteristiques de cette enzyme (localisation tissulaire, poids moleculaire…) et ses parametres cinetiques, sont ...
S M, Sebti, J S, Lazo
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Individual Variation in the Activation and Inactivation of Metabolic Pathways of Cyclophosphamide
JNCI Journal of the National Cancer Institute, 1992Carboxyphosphamide is an inactive metabolite of cyclophosphamide, which is a widely used antineoplastic drug. Deficiencies in the production of this metabolite have been reported. Such deficiencies would have important consequences for therapeutic and toxic effects of oxazaphosphorines like cyclophosphamide.This study further investigates the ...
Boddy +8 more
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Metabolic inactivation of vitamin D is enhanced in primary hyperparathyroidism
Clinical Science, 19871. The elimination half-time of 25-hydroxyvitamin D in plasma was estimated after intravenous injection of the radioactively labelled metabolite in seven patients with primary hyperparathyroidism before and after excision of a parathyroid adenoma. 2.
M R, Clements +5 more
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Effect of cobalamin inactivation on folate metabolism of leukemic cells
Leukemia Research, 1988Exposure to nitrous oxide inactivates the cobalamin coenzyme of methionine synthetase, an essential enzyme in folate metabolism. Hemopoietic cells are especially dependent on the function of cobalamin for the folate-dependent synthesis of thymidylate (dTMP).
A A, Ermens +5 more
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Metabolic and phenotypic adaptations of diaphragm muscle fibers with inactivation
Journal of Applied Physiology, 1997Zhan, Wen-Zhi, Hirofumi Miyata, Y. S. Prakash, and Gary C. Sieck. Metabolic and phenotypic adaptations of diaphragm muscle fibers with inactivation. J. Appl. Physiol. 82(4):1145–1153, 1997.—We hypothesized that metabolic adaptations to muscle inactivity are most pronounced when neurotrophic influence is disrupted.
W Z, Zhan +3 more
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