Results 221 to 230 of about 163,771 (263)

inactivation in vitro of microsomal oxidases during parathion metabolism

Biochemical Pharmacology, 1978
Abstract The inactivation in vitro of microsomal oxidases during parathion metabolism was examined in relation to the binding to the microsomal membrane of sulfur resulting from desulfuration. Modulation of sulfur binding with sulfhydryl compounds revealed that the majority of bound sulfur is unrelated to inactivation.
M A, Morelli, T, Nakatsugawa
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Tyrosine transaminase: Inactivation by tyrosine metabolic end products

Biochimica et Biophysica Acta (BBA) - Enzymology, 1970
Abstract The tyrosine metabolites, p- hydroxyphenylpyruvate , homogentisate, and fumarylacetoacetate were examined as inhibitors and inactivators of purified rat liver tyrosine α-ketoglutarate transaminase. Of these, homogentisate proved to be a very powerful inactivator when the enzyme was preincubated with it. This effect was blocked by prior
M, Civen, C, Wilson, C B, Brown
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Metabolism of enkephalins and the inactivating neuropeptidase concept

Trends in Neurosciences, 1983
Abstract The potentiation of the effects of enkephalin on target cells by selective peptidase inhibitors raises the possibility that peptidergic signals are turned off not only by diffusion but also by hydrolysis by ‘neuropeptidases'. Two recently identified peptidases are likely to play such a role in enkephalinergic neurotransmission, and their ...
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Interethnic variation in the metabolic inactivation of digoxin by the gut flora

Gastroenterology, 1988
Digoxin is metabolized to cardioinactive reduced metabolites (digoxin reduction products) in some patients by anaerobic bacteria present in the gut flora. We compared the tendencies of Americans and Bangladeshis to reduce digoxin by this pathway. Of 97 normal Americans in New York City, 34 (35.1%) were metabolizers in contrast to 14 of 100 Bangladeshis
A N, Alam, J R, Saha, J F, Dobkin, J, Lindenbaum   +3 more
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Lack of mutagenicity and metabolic inactivation of aphidicolin by rat liver microsomes

Biochemical and Biophysical Research Communications, 1980
Abstract In view of the possible utilization of aphidicolin, a specific inhibitor of DNA polymerase α, in the treatment of neoplastic diseases, it seemed important to assess the mutagenic effect of the drug and the possible modification induced by metabolic activation in the liver.
PEDRALINOY G, MAZZA G, FOCHER F, SPADARI S   +3 more
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SELECTIVE INACTIVATION OF MICROSOMAL DRUG METABOLIZING PROTEINS BY VISIBLE LIGHT

Photochemistry and Photobiology, 1981
Abstract— Rat liver microsomes treated with heterochromatic visible light (λ > 400 nm) and O2 showed a preferential inactivation of NADPH‐cytochrome P450 reductase and cytochrome P450, proteins involved in drug metabolism. Cytochrome P450 destruction correlates with lipid peroxidation; both are oxygen dependent and affected to the same extent by ...
O, Augusto, L, Packer
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Catecholamine Metabolism: Biosynthesis, Storage, Release, and Inactivation

1977
Basic to an understanding of the pathophysiology of pheochromocytoma is a knowledge of the biosynthesis and inactivation of the catecholamines. The term “catecholamine” refers to any compound composed of a catechol nucleus (a benzene ring with two adjacent hydroxyl groups) and an aminecontaining side chain; these substances are of low molecular weight.
William Muir Manger, Ray W. Gifford
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Effect of oestrogens and progesterone on the metabolic inactivation of noradrenaline in the human placenta

International Journal of Gynecology & Obstetrics, 1988
The enzymatic inactivation of noradrenaline was investigated in 25 fresh human placentae in vitro. Oxidative deamination by monoamine oxidase (MAO) was greater than enzymic O-methylation by catechol-O-methyltransferase (COMT). The addition of oestriol (E3) or progesterone to the organ bath significantly decreased (P less than 0.001) the activity of ...
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Metabolically Inactivated Glucocorticoids

2023
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Physiological limitations and opportunities in microbial metabolic engineering

Nature Reviews Microbiology, 2021
JOSÉ L Avalos, JOSÉ Montano Lopez, Avalos JOSÉ L   +2 more
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