Results 21 to 30 of about 2,032,731 (300)
Compartmentalization and metabolic regulation of glycolysis.
Journal of Cell Science, 2021 Hypoxia inhibits the tricarboxylic acid (TCA) cycle and leaves glycolysis as the primary metabolic pathway responsible for converting glucose into usable energy.
Gregory G. Fuller, John K. Kim
semanticscholar +1 more source
Mutant TDP-43 deregulates AMPK activation by PP2A in ALS models. [PDF]
PLoS ONE, 2014 Bioenergetic abnormalities and metabolic dysfunction occur in amyotrophic lateral sclerosis (ALS) patients and genetic mouse models. However, whether metabolic dysfunction occurs early in ALS pathophysiology linked to different ALS genes remains unclear.
Nirma D Perera +5 more
doaj +3 more sources
Auxin-mediated protein depletion for metabolic engineering in terpene-producing yeast
Nature Communications, 2021 In metabolic engineering, loss-of-function experiments are used to understand and optimise metabolism. A conditional gene inactivation tool is required when gene deletion is lethal or detrimental to growth.
Zeyu Lu +4 more
semanticscholar +1 more source
Inactivation of Insulin by Intermediary Fat Metabolism Products [PDF]
Nature, 1946 IT has been recorded by several workers that insulin, though effective in most diabetics in lowering the blood-sugar level to normal, in a small fraction of cases either does not react at all or very high doses are required for beneficial results. Rosenthal1 observed that one of his patients showed no relief in hyperglycaemia even by daily injections ...
M C, NATH, H D, BRAHMACHARI
openaire +2 more sources
Scientific Reports, 2016 Prolyl hydroxylase domain protein 2 (PHD2) belongs to an evolutionarily conserved superfamily of 2-oxoglutarate and Fe(II)-dependent dioxygenases that mediates homeostatic responses to oxygen deprivation by mediating hypoxia-inducible factor-1α (HIF-1α ...
Gibok Lee +11 more
semanticscholar +1 more source
BMC Systems Biology, 2015 BackgroundThe bacterium Pseudomonas fluorescens switches to an alginate-producing phenotype when the pleiotropic anti-sigma factor MucA is inactivated.
Stina K. Lien +4 more
semanticscholar +1 more source
Scientific Reports, 2021 Wilson disease (WD) is caused by inactivation of the copper transporter Atp7b and copper overload in tissues. Mice with Atp7b deleted either globally (systemic inactivation) or only in hepatocyte recapitulate various aspects of human disease.
Abigael Muchenditsi +10 more
doaj +1 more source
Metabolism and inactivation of neurotransmitters in nematodes
Parasitology, 1996 SUMMARYThe nematode nervous system employs many of the same neurotransmitters as are found in higher animals. The inactivation of neurotransmitters is absolutely essential for the correct functioning of the nervous system, In this article we discuss the various mechanisms used generally in animal nervous systems for synaptic inactivation of ...
R E, Isaac, D, MacGregor, D, Coates
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Cystathionine γ-Lyase Self-Inactivates by Polysulfidation during Cystine Metabolism
International Journal of Molecular Sciences, 2023 Cystathionine γ-lyase (CSE) is an enzyme responsible for the biosynthesis of cysteine from cystathionine in the final step of the transsulfuration pathway. It also has β-lyase activity toward cystine, generating cysteine persulfide (Cys-SSH). The chemical reactivity of Cys-SSH is thought to be involved in the catalytic activity of particular proteins ...
Shoma Araki +9 more
openaire +2 more sources
PAS Kinase: A Nutrient and Energy Sensor “Master Key” in the Response to Fasting/Feeding Conditions
Frontiers in Endocrinology, 2020 The protein kinase with PAS domains (PASK) is a nutrient and energy sensor located in the cells of multiple organs. Many of the recent findings for understanding PASK functions in mammals have been reported in studies involving PASK-deficient mice.
Verónica Hurtado-Carneiro +4 more
doaj +1 more source