Results 31 to 40 of about 2,032,731 (300)

Promotion of healthy adipose tissue remodeling ameliorates muscle inflammation in a mouse model of sarcopenic obesity

Frontiers in Nutrition, 2023
A large subset of elders is classified as having sarcopenic obesity, a prevalence of obesity in combination with sarcopenia which places an aging population at the risk of adverse health consequences from both conditions.
Yunlin Ge, Siqi Li, Siqi Li, Tao Yao, Yuexiao Tang, Yuexiao Tang, Qiangyou Wan, Xiaoli Zhang, Jing Zhao, Mingliang Zhang, Mengle Shao, Lijun Wang, Lijun Wang, Ying Wu, Ying Wu, Ying Wu   +15 more
doaj   +1 more source

Effects of tendamistate (alpha‐amylase inactivator) on starch metabolism. [PDF]

British Journal of Clinical Pharmacology, 1983
Abstract 1 Tendamistate (Hoe 467) reduces gastrointestinal absorption of starch by inactivating α-amylase. 2 Two trials were performed to investigate the influence of timing and mode of administration of tendamistate, relative to starch intake, on the pharmacodynamics of the drug. (i) In the first trial 400 mg enteric coated capsules, 400 mg non-
B H, Meyer, F O, Müller, B K, Clur, H G, Grigoleit   +3 more
openaire   +2 more sources

ATM Couples Replication Stress and Metabolic Reprogramming during Cellular Senescence

Cell Reports, 2015
Replication stress induced by nucleotide deficiency plays an important role in cancer initiation. Replication stress in primary cells typically activates the cellular senescence tumor-suppression mechanism.
Katherine M. Aird, Andrew J. Worth, Nathaniel W. Snyder, Joyce V. Lee, Sharanya Sivanand, Qin Liu, Ian A. Blair, Kathryn E. Wellen, Rugang Zhang   +8 more
doaj   +1 more source

E2F/Dp inactivation in fat body cells triggers systemic metabolic changes

eLife, 2021
The E2F transcription factors play a critical role in controlling cell fate. In Drosophila, the inactivation of E2F in either muscle or fat body results in lethality, suggesting an essential function for E2F in these tissues.
Maria Paula Zappia, Ana Guarner, Nadia Kellie-Smith, Alice Rogers, Robert Morris, Brandon Nicolay, Myriam Boukhali, Wilhelm Haas, Nicholas J Dyson, Maxim V Frolov   +9 more
doaj   +1 more source

A Comparative Analysis of the Metabolomic Response of Electron Beam Inactivated E. coli O26:H11 and Salmonella Typhimurium ATCC 13311

Frontiers in Microbiology, 2019
Ionizing radiation such as Electron beam (EB) and gamma irradiation inactivate microbial cells preventing their multiplication. These cells, however, are structurally intact and appear to have residual metabolic activity.
Sohini S. Bhatia, Suresh D. Pillai
doaj   +1 more source

CFDA-AM staining to assess the metabolic activity of Giardia duodenalis cysts inactivated by chlorine, boiling and ultraviolet irradiation

Journal of Water and Health, 2022
Giardia duodenalis is responsible for several waterborne gastrointestinal outbreaks worldwide. In addition to limitations presented by the main disinfection methods, assessing the inactivation efficiency of cysts after the treatment also poses challenges.
Maria Júlia Rodrigues da Cunha, Bárbara Luíza Souza Freitas, Natália de Melo Nasser Fava, Lyda Patricia Sabogal-Paz   +3 more
doaj   +1 more source

Chronic AMPK inactivation slows SHH medulloblastoma progression by inhibiting mTORC1 signaling and depleting tumor stem cells

iScience, 2023
Summary: We show that inactivating AMPK in a genetic medulloblastoma model depletes tumor stem cells and slows progression. In medulloblastoma, the most common malignant pediatric brain tumor, drug-resistant stem cells co-exist with transit-amplifying ...
Daniel Shiloh Malawsky, Taylor Dismuke, Hedi Liu, Ethan Castellino, Jay Brenman, Biplab Dasgupta, Andrey Tikunov, Timothy R. Gershon   +7 more
doaj   +1 more source

Lysosomal Signaling Licenses Embryonic Stem Cell Differentiation via Inactivation of Tfe3.

Cell Stem Cell, 2019
Self-renewal and differentiation of pluripotent murine embryonic stem cells (ESCs) is regulated by extrinsic signaling pathways. It is less clear whether cellular metabolism instructs developmental progression.
Florian Villegas, D. Lehalle, Daniela Mayer, Melanie Rittirsch, Michael B. Stadler, Marietta Zinner, Daniel Olivieri, Pierre Vabres, Laurence Duplomb-Jego, E. D. de Bont, Y. Duffourd, F. Duijkers, Magali Avila, D. Geneviève, N. Houcinat, T. Jouan, P. Kuentz, K. Lichtenbelt, C. Thauvin-Robinet, J. St‐Onge, J. Thevenon, K. V. van Gassen, M. van Haelst, S. van Koningsbruggen, D. Hess, Sébastien A. Smallwood, J. Rivière, L. Faivre, Joerg Betschinger   +28 more
semanticscholar   +1 more source

Single or combined ablation of peripheral serotonin and p21 limit adipose tissue expansion and metabolic alterations in early adulthood in mice fed a normocaloric diet.

PLoS ONE, 2021
Identifying the fundamental molecular factors that drive weight gain even in the absence of hypercaloric food intake, is crucial to enable development of novel treatments for the global pandemic of obesity.
Enrica Saponara, Rong Chen, Theresia Reding, Richard Zuellig, Darren C Henstridge, Rolf Graf, Sabrina Sonda   +6 more
doaj   +2 more sources

Systemic inactivation of hypoxia-inducible factor prolyl 4-hydroxylase 2 in mice protects from alcohol-induced fatty liver disease

Redox Biology, 2019
Alcoholic fatty liver disease (AFLD) is a growing health problem for which no targeted therapy is available. We set out to study whether systemic inactivation of the main hypoxia-inducible factor prolyl 4-hydroxylase, HIF-P4H-2 (PHD2/EglN1), whose ...
Anna Laitakari, Teemu Ollonen, Thomas Kietzmann, Gail Walkinshaw, Daniela Mennerich, Valerio Izzi, Kirsi-Maria Haapasaari, Johanna Myllyharju, Raisa Serpi, Elitsa Y. Dimova, Peppi Koivunen   +10 more
doaj   +1 more source