Results 41 to 50 of about 369,106 (309)

Two Faces of NOTCH1 in Childhood Lymphoblastic T‐Cell Neoplasia: Prognostic Divergence of Mutational and Structural Aberrations

Pediatric Blood &Cancer, EarlyView.
ABSTRACT In pediatric patients, T‐cell lymphoblastic lymphoma (T‐LBL) survival exceeds 80%. Relapse remains associated with limited curative options. Frontline treatment is largely extrapolated from T‐cell acute lymphoblastic leukemia (T‐ALL) treatment, reflecting the ongoing debate, whether both entities represent distinct diseases or variants within ...
Marie C. Heider, Amelie Alfert, Marc Hotfilder, Birgit Burkardt, Marcel te Vrugt   +4 more
wiley   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

The Effect of Bed Rest and Hypoxic Environment on Postural Balance and Trunk Automatic (Re)Actions in Young Healthy Males

Frontiers in Physiology, 2018
Prolonged inactivity, such as bed rest induces several detrimental changes within a short timeframe. Impaired postural balance and responses of trunk muscles to (un)expected perturbations were both shown to be impaired after bed rest. Certain populations
Nejc Šarabon, Nejc Šarabon, Igor B. Mekjavić, Igor B. Mekjavić, Ola Eiken, Jan Babič   +5 more
doaj   +1 more source

Sedentary Conditions Promote Subregionally Specific Changes in Brain-Derived Neurotrophic Factor in the Rostral Ventrolateral Medulla

Frontiers in Physiology, 2021
A sedentary lifestyle is the top preventable cause of death and accounts for substantial socioeconomic costs to society. The rostral ventrolateral medulla regulates blood pressure under normal and pathophysiological states, and demonstrates inactivity ...
Bozena E. Fyk-Kolodziej, Patrick J. Mueller   +1 more
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Systems View of Deconditioning During Spaceflight Simulation in the PlanHab Project: The Departure of Urine 1 H-NMR Metabolomes From Healthy State in Young Males Subjected to Bedrest Inactivity and Hypoxia

Frontiers in Physiology, 2020
We explored the metabolic makeup of urine in prescreened healthy male participants within the PlanHab experiment. The run-in (5 day) and the following three 21-day interventions [normoxic bedrest (NBR), hypoxic bedrest (HBR), and hypoxic ambulation (HAmb)
Robert Šket, Leon Deutsch, Zala Prevoršek, Igor B. Mekjavić, Janez Plavec, Joern Rittweger, Tadej Debevec, Tadej Debevec, Ola Eiken, Blaz Stres, Blaz Stres, Blaz Stres, Blaz Stres, Blaz Stres   +13 more
doaj   +1 more source

Modelling Future Coronary Heart Disease Mortality to 2030 in the British Isles. [PDF]

, 2015
OBJECTIVE: Despite rapid declines over the last two decades, coronary heart disease (CHD) mortality rates in the British Isles are still amongst the highest in Europe.
A Martin, Alastair H. Leyland, B Unal, C Ji, Carolyn Davies, CJ Murray, E Vartiainen, F Bull, FJ He, Frank Kee, H Tunstall-Pedoe, J Hughes, J Ruszkowska-Majzel, Joel W. Hotchkiss, John Hughes, Julia Critchley, Kathleen Bennett, LJ Cobiac, M Bajekal, M Ezzati, M Scollo, M Ward, MA Wakefield, Maria Guzman-Castillo, Martin O’Flaherty, P Puska, P Scarborough, Piotr Bandosz, R Clarke, S Adams, S Capewell, S Capewell, S Capewell, Simon Capewell, T Shimamoto, Yiru Guo, Z Kabir, Zubair Kabir   +37 more
core   +4 more sources

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

California Adolescents Increasingly Inactive [PDF]

, 2005
Explores the health benefits of regular exercise; the extent to which adolescents in California are getting adequate levels of physical activity; and factors that affect high rates of inactivity.
Allison L. Diamant, E. Richard Brown, Susan H. Babey, Theresa A. Hastert   +3 more
core   +1 more source

The active living gender's gap challenge: 2013-2017 Eurobarometers physical inactivity data show constant higher prevalence in women with no progress towards global reduction goals [PDF]

, 2019
BACKGROUND: The World Health Organization (WHO) considers physical inactivity (PIA) as a critical noncommunicable factor for disease and mortality, affecting more women than men.
A Alkerwi, A Van Hoye, A. Jimenez, A. Lowe, D Ding, E von Elm, E. Iglesias-Soler, European Opinion Research Group, European Opinion Research Group, F. del Villar, FT Filippidis, G. Liguori, GI Mielke, H Cheng, H Spittaels, I. Clavel San Emeterio, International Physical Activity Questionnaire, J Van Cauwenberg, JF Sallis, M Sjöström, MN van Poppel, NV Christiansen, PH Lee, R Guthold, R Guthold, R Rzewnicki, R Van Acker, R. J. Copeland, T Lebacq, V Dubuy, V Gerovasili, X Mayo, X. Mayo   +32 more
core   +4 more sources