Results 101 to 110 of about 45,424 (315)
Molecular Genetics and Metabolism Reports, 2016 The Congenital Disorders of Glycosylation (CDG) are an expanding group of genetic disorders which encompass a spectrum of glycosylation defects of protein and lipids, including N- & O-linked defects and among the latter are the muscular ...
Wendy E. Heywood +11 more
doaj +1 more source
Hessian continuity at degenerate points in nonvariational elliptic problems [PDF]
arXiv, 2012 Established in the 30's, Schauder {\it a priori} estimates are among the most classical and powerful tools in the analysis of problems ruled by 2nd order elliptic PDEs. Since then, a central problem in regularity theory has been to understand Schauder type estimates fashioning particular borderline scenarios.
arxiv
Advanced Science, EarlyView.Sturge‐Weber syndrome (SWS) is characterized by leptomeningeal vascular malformations, leading to seizures and stroke. Analysis of 119 446 brain cells from SWS patients uncovered distinct cell heterogeneity and identified an EDN3⁺ meningeal fibroblast cluster, with WNT5A emerging as a potential key driver of SWS progression and a promising therapeutic ...
Daosheng Ai +14 more
wiley +1 more source
Treatment of inborn errors of metabolism [PDF]
Molecular Cytogenetics, 2014 Inborn errors of metabolism (IEM), though individually rare are collectively common. Average incidence of 50+ common IEMs is considered to be approx 1 in 1,000 live births. With annual birth rate of approximately 25 million babies in India, we can expect at least 25,000 babies being born with IEM in India and hence it is a significant burden to the ...
openaire +3 more sources
Advanced Science, EarlyView.Overview of the Genetic Deafness Commons (GDC), integrating data from the Chinese Deafness Genetics Consortium (CDGC) and 51 public databases. The GDC provides tools for variant search, functional predictions, and gene‐disease visualization, offering insights into 201 hearing loss genes and facilitating novel gene discovery and clinical applications ...
Hui Cheng +11 more
wiley +1 more source
Silicon Nitride Waveguides for Plasmon Optical Trapping and Sensing Applications [PDF]
arXiv, 2015 We demonstrate a silicon nitride trench waveguide deposited with bowtie antennas for plasmonic enhanced optical trapping. The sub-micron silicon nitride trench waveguides were fabricated with conventional optical lithography in a low cost manner. The waveguides embrace not only low propagation loss and high nonlinearity, but also the inborn merits of ...
arxiv
Artesunate Inhibits Neointimal Hyperplasia by Promoting IRF4 Associated Macrophage Polarization
Advanced Science, EarlyView.This study shows that macrophage interferon regulatory factor 4 (IRF4) improved arterial injury‐induced neointimal hyperplasia by promoting of M2 polarization via up‐regulating krüppel‐like factor 4 (KLF4) in rodent and nonhuman primate models. Notably, artesunate is identified as a potent inducer of IRF4 in macrophages, and proposed as a promising ...
Jinlin Miao +15 more
wiley +1 more source
Truly Visual Polymorphic Algebraic Data Structures through Maramafication [PDF]
arXiv, 2018 This paper presents a so-called maramafication of an essential part of functional programming languages such as Haskell or Clean: the construction of fully polymorphic well-typed algebraic data structures based on type definitions with at most one type parameter.
arxiv
Programmed Fabrication of Vesicle‐Based Prototissue Fibers with Modular Functionalities
Advanced Science, EarlyView.The fabrication of freestanding vesicle‐based prototissue fibers is reported. The lengths, diameters, and shapes of the fibers can be well‐controlled. Multimodular fibers with different prototissues can be fabricated. Focusing on modularity, manipulation functionalities are obtained when connected with magnetic fibers.
Tomoya Kojima +3 more
wiley +1 more source