Results 101 to 110 of about 48,814 (291)

Evaluation of the PP6D5 Polymer as a Novel Non-Viral Vector in the Development of a CRISPR/nCas9-Based Gene Therapy for Tay–Sachs Disease

Pharmaceutics
Background/Objectives: Tay–Sachs disease (TSD) is a neurodegenerative disorder caused by a deficiency in β-hexosaminidase A (HexA), which accumulates GM2 gangliosides, primarily in neurons.
Jacky M. Guerrero-Vargas, Diego A. Suarez-Garcia, Andrés F. Leal, Ivonne L. Diaz-Ariza, León D. Pérez-Pérez, Angela J. Espejo-Mojica, Carlos J. Alméciga-Díaz   +6 more
doaj   +1 more source

Clinical aspects of inborn metabolic defects [PDF]

, 1962
Philip R. Evans
openalex   +1 more source

Highly Stretchable, Adhesive, and Conductive PEDOT Nanocomposite Hydrogels for High‐Performance Flexible Bioelectronics

Advanced Science, EarlyView.
A multifunctional and water‐soluble conductive nanocomposite is fabricated by employing tannic acid‐modified MXene as a template to direct the in situ polymerization of poly(3,4‐ethylenedioxythiophene) (PEDOT). The resulting PEDOT nanosheets are uniformly integrated into hydrogel networks, simultaneously imparting stretchability (>800%), strong tissue ...
Huiqi Sun, Sai Wang, Peipei Wang, Ling Bai, Mingyi Tan, Fan Yang, Rongguo Wang, Xiaodong He   +7 more
wiley   +1 more source

Book Review: Brain Damage by Inborn Errors of Metabolism [PDF]

, 1969
E. F. Scowen
openalex   +1 more source

A Forward Genetics Strategy for High‐Throughput Gene Identification via Precise Image‐Based Phenotyping of an Indexed EMS Mutant Library

Advanced Science, EarlyView.
The GeneHunter‐Gene‐Level Association (GH‐GLA) pipeline enables high‐throughput gene identification in an indexed EMS population of wheat cultivar KN9204. It identifies 5905 trait‐associated wheat genes and validates key regulators of kernel weight and spikelet architecture via gene editing and haplotype analysis.
Haojie Wang, Fujun Sun, Zeyu Shi, Yufeng Yang, Yi Ding, Tengteng Zhang, Caihong Zhao, Jingzhong Xie, Yaqian Zhang, Caihua Li, Wenqiang Tang, Junming Li, Xigang Liu, Shusong Zheng, Ni Jiang, Fei He, Shuzhi Zheng   +16 more
wiley   +1 more source

Inborn Errors of Metabolism in Neurology (Wilson's Disease, Refsum's Disease and Lipidoses) [PDF]

, 1971
J. N. Cumings
openalex   +1 more source

Logistic Regression and Machine Learning Algorithms for the Risk Prediction of Perioperative Adverse Cardiovascular Events in Elderly Patients

AGING MEDICINE, EarlyView.
This manuscript focused on developing and validating prediction models for PACEs in elderly patients undergoing noncardiac surgery in China, utilizing routine laboratory examination findings. Logistic regression and machine learning algorithms were employed to construct these models.
Xiao Yan Li, Guang You Duan, Lin Li, Yi Yuan Gao, Li Wen Sun, Silin Zhu, Xiyezi Diao, Ning Wang, He Huang   +8 more
wiley   +1 more source

Alpha-ketoadipic aciduria, a new inborn error of lysine metabolism; biochemical studies [PDF]

, 1975
Hildegard Przyrembel, Dorothea Bachmann, I. Lombeck, Kathrin Becker, U. Wendel, S.K. Wadman, H. J. Bremer   +6 more
openalex   +1 more source

Using Sensory Analysis and Stated Preference Valuation to Assess the Willingness to Pay for Fresh Tomato Attributes

Agribusiness, EarlyView.
ABSTRACT This study combines sensory analysis and stated preference valuation techniques to assess the monetary value of organoleptic attributes of new tomato varieties. The tomatoes evaluated included two new varieties adapted to South Texas growing conditions, a commercial check, and tomatoes imported from Mexico.
Samuel D. Zapata, Xavier A. Villavicencio, Thiago G. Marconi, Carlos A. Avila   +3 more
wiley   +1 more source

Machine Learning‐Assisted Infectious Disease Detection in Low‐Income Areas: Toward Rapid Triage of Dengue and Zika Virus Using Open‐Source Hardware

Advanced Intelligent Discovery, EarlyView.
This study introduces an affordable machine learning platform for simultaneous dengue and zika detection using fluorine‐doped tin oxide thin films modified with gold nanoparticles and DNA aptamers. Designed for low‐cost, hardware‐limited devices (< $25), the model achieves 95.3% accuracy and uses only 9.4 kB of RAM, demonstrating viability for resource‐
Marina Ribeiro Batistuti Sawazaki, Bassam Bachour Junior, Marcelo Mulato, José Ilton de Oliveira Filho   +3 more
wiley   +1 more source