Results 201 to 210 of about 15,070 (233)
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Otitis Media and Inborn Errors of Immunity
Current Allergy and Asthma Reports, 2020The aim of this review is as follows: (1) to present the role of otitis as a warning sign for inborn errors of immunity (IEI), (2) to establish which patients presenting otitis should be investigated for IEI, (3) to review data about main IEI associated with otitis-prone patients.Otitis media is a very common infection in general population.
Daniele Pontarolli +2 more
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Gene Therapy for Inborn Errors of Immunity
The Journal of Allergy and Clinical Immunology: In Practice, 2023In the early 1990s, gene therapy (GT) entered the clinical arena as an alternative to hematopoietic stem cell transplantation for forms of inborn errors of immunity (IEIs) that are not medically manageable because of their severity. In principle, the use of gene-corrected autologous hematopoietic stem cells presents several advantages over ...
Tiphaine Arlabosse +2 more
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Approach to Diagnosing Inborn Errors of Immunity
Rheumatic Disease Clinics of North America, 2023Inborn errors of immunity are now understood to encompass manifold features including but not limited to immunodeficiency, autoimmunity, autoinflammation, atopy, bone marrow defects, and/or increased malignancy risk. As such, it is essential to maintain a high index of suspicion, as these disorders are not limited to specific demographics such as ...
Xiao, Peng, Saara, Kaviany
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COVID-19 and Inborn Errors of Immunity
Physiology, 2022Inborn errors of immunity (IEI) are a heterogeneous group of disorders affecting immune host defense and immunoregulation. Considering the predisposition to develop severe and chronic infections, it is crucial to understand the clinical evolution of COVID-19 in IEI patients.
Ottavia M. Delmonte +2 more
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The lung in inborn errors of immunity
Pediatric PulmonologyAbstractThe lungs are integral to immune defense, and inborn errors of immunity (IEI) often manifest as lung disease. Lung complications of IEI can involve the airways, alveolar spaces, interstitium, vasculature, and pleura. Accurate identification of these lung disease patterns requires a thorough clinical history, physical examination, and high ...
Sonia Restrepo‐Gualteros +2 more
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Thymic inborn errors of immunity
Journal of Allergy and Clinical ImmunologyThe thymus is crucial for optimal T-cell development by facilitating the generation and selection of a diverse repertoire of T cells that can recognize foreign antigens while promoting tolerance to self-antigens. A number of inborn errors of immunity causing complete or partial defects in thymic development (athymia) and/or impaired thymic function ...
Francesca, Pala +2 more
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Proteasome disorders and inborn errors of immunity
Immunological Reviews, 2023SummaryInborn errors of immunity (IEI) or primary immune deficiencies (PIDD) are caused by variants in genes encoding for molecules that are relevant to the innate or adaptive immune response. To date, defects in more than 450 different genes have been identified as causes of IEI, causing a constellation of heterogeneous clinical manifestations ranging
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Inborn Errors of Immunity and Cancers
2020Primary immunodeficiencies (PIDs) result from defects in genes affecting the immune and other systems in many and varied ways, which collectively predisposes to frequent and severe infections, autoimmune disorders, and cancers. Until recently, treatments of PIDs have been largely supportive, with the exception of bone marrow transplantation.
Mona Hedayat +8 more
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Viral infections and inborn errors of immunity
Current Opinion in Infectious DiseasesPurpose of review The purpose of this focused review is to discuss unusual presentations of viral infections in the context of specific inborn errors of immunity. We will discuss hyper immunoglobulin E (IgE) syndromes, epidermodysplasia verruciformis, and X-linked agammaglobulinemia as examples of inborn errors of immunity ...
Anne, Ewing, Rebecca Pellett, Madan
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Exponential suppression of bit or phase errors with cyclic error correction
Nature, 2021Kevin J Satzinger +2 more
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