Syndromic Inborn Errors of Immunity in TREC-Newborn Screening: 5-year Experience from the German Screening Program. [PDF]
Graafen L +32 more
europepmc +1 more source
Liver transplantation: a 31-year perspective. Part I. [PDF]
Adler +212 more
core +1 more source
Population Pharmacokinetics of Clesrovimab in Preterm and Full‐Term Infants
Clesrovimab is a half‐life extended monoclonal antibody targeting the respiratory syncytial virus fusion protein. Three studies (phase Ib/IIa [MK‐1654‐002], phase IIb/III [CLEVER], and phase III [SMART]) were conducted to evaluate the efficacy, safety, and pharmacokinetics (PK) of clesrovimab in infants.
Ziheng Hu +8 more
wiley +1 more source
Incomplete penetrance in inborn errors of immunity: A skeleton in the closet-The sequel. [PDF]
Bogunovic D.
europepmc +1 more source
ABSTRACT Noonan syndrome (NS) is a RASopathy that can have hematological presentations, most commonly NS‐related myeloproliferative disorder (NS/MPD) and juvenile myelomonocytic leukemia. Other neonatal hematologic presentations remain poorly defined.
Ariel Gershon +4 more
wiley +1 more source
Allergic manifestations in inborn errors of immunity: a systematic scoping review. [PDF]
Marbet L +7 more
europepmc +1 more source
The Homeobox Genes: Classification, Regulation, Biological Functions, and Diseases
Overview of the homeobox gene superfamily and its pathophysiological roles. The homeobox superfamily comprises several major classes, including ANTP, PRD, TALE, LIM, POU, and others. Among these, the HOX clusters (A–D) play critical roles in embryonic development specifically in conferring cellular identity, regulating morphogenesis, and guiding axial ...
Maedeh Dadzadi +5 more
wiley +1 more source
Atopic dermatitis in inborn errors of immunity: at the interface of immunodeficiency and immune dysregulation. [PDF]
Szczawińska-Popłonyk A.
europepmc +1 more source
Unraveling Chronic Pain: From Mechanisms and Risks to Diagnosis and Treatment
Chronic pain arises through distinct molecular pathways categorized into nociceptive, neuropathic, and nociplastic types. Nociceptive pain begins with TRP channel activation in peripheral nociceptors, signaling via Aδ‐ and C‐fibers through the spinal dorsal horn and spinothalamic tracts to the brain, regulated by descending inhibition and involving ...
Xiaofeng Dai +3 more
wiley +1 more source
The prevalence of allergic manifestations in inborn errors of immunity: a retrospective cohort study. [PDF]
Esmaeilzadeh H +4 more
europepmc +1 more source

