Results 201 to 210 of about 7,049 (225)
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Gene Therapy for Inborn Errors of Immunity
The Journal of Allergy and Clinical Immunology: In Practice, 2023In the early 1990s, gene therapy (GT) entered the clinical arena as an alternative to hematopoietic stem cell transplantation for forms of inborn errors of immunity (IEIs) that are not medically manageable because of their severity. In principle, the use of gene-corrected autologous hematopoietic stem cells presents several advantages over ...
Tiphaine Arlabosse +2 more
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Approach to Diagnosing Inborn Errors of Immunity
Rheumatic Disease Clinics of North America, 2023Inborn errors of immunity are now understood to encompass manifold features including but not limited to immunodeficiency, autoimmunity, autoinflammation, atopy, bone marrow defects, and/or increased malignancy risk. As such, it is essential to maintain a high index of suspicion, as these disorders are not limited to specific demographics such as ...
Xiao, Peng, Saara, Kaviany
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The lung in inborn errors of immunity
Pediatric PulmonologyAbstractThe lungs are integral to immune defense, and inborn errors of immunity (IEI) often manifest as lung disease. Lung complications of IEI can involve the airways, alveolar spaces, interstitium, vasculature, and pleura. Accurate identification of these lung disease patterns requires a thorough clinical history, physical examination, and high ...
Sonia Restrepo‐Gualteros +2 more
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Inborn errors of immunity: Recent progress
Journal of Allergy and Clinical Immunology, 2021Recent advances in the field of inborn errors of immunity (IEIs) have been wide in scope, including progress in mechanisms of disease, diagnosis, and management. New gene defects affecting the immune response continue to be reported, as many as 26 in the year 2020.
Neha, Seth +2 more
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Nocardia in inborn errors in immunity
Infectious DiseasesNocardiosis is caused by the Gram-positive bacterium Nocardia spp. The most common inborn error in immunity (IEI) associated with nocardiosis is chronic granulomatous disease (CGD). This case series highlights five cases of nocardiosis with a diagnosis of IEI other than CGD.
Syuna Salgaonkar +5 more
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Otitis Media and Inborn Errors of Immunity
Current Allergy and Asthma Reports, 2020The aim of this review is as follows: (1) to present the role of otitis as a warning sign for inborn errors of immunity (IEI), (2) to establish which patients presenting otitis should be investigated for IEI, (3) to review data about main IEI associated with otitis-prone patients.Otitis media is a very common infection in general population.
Maine L D, Bardou +2 more
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Proteasome disorders and inborn errors of immunity
Immunological Reviews, 2023SummaryInborn errors of immunity (IEI) or primary immune deficiencies (PIDD) are caused by variants in genes encoding for molecules that are relevant to the innate or adaptive immune response. To date, defects in more than 450 different genes have been identified as causes of IEI, causing a constellation of heterogeneous clinical manifestations ranging
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Viral infections and inborn errors of immunity
Current Opinion in Infectious DiseasesPurpose of review The purpose of this focused review is to discuss unusual presentations of viral infections in the context of specific inborn errors of immunity. We will discuss hyper immunoglobulin E (IgE) syndromes, epidermodysplasia verruciformis, and X-linked agammaglobulinemia as examples of inborn errors of immunity ...
Anne, Ewing, Rebecca Pellett, Madan
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