Biomédica: revista del Instituto Nacional de SaludIntroduction. Inborn errors of immunity include a broad spectrum of genetic diseases, in which a specific gene mutation might alter the entire emphasis and approach for an individual patient. Objective.
Mónica Fernandes Pineda +1 more
doaj +1 more source
Pro-inflammatory signaling by IL-10 and IL-22: bad habit stirred up by interferons? [PDF]
, 2013 Interleukin (IL)-10 and IL-22 are key members of the IL-10 cytokine family that share characteristic properties such as defined structural features, usage of IL-10R2 as one receptor chain, and activation of signal transducer and activator of ...
Mühl, Heiko
core +2 more sources
Vaccination for Patients with Inborn Errors of Immunity: a Nationwide Survey in Japan [PDF]
, 2021 Sho Hosaka +6 more
openalex +2 more sources
STAT2 deficiency and susceptibility to viral illness in humans [PDF]
, 2013 Severe infectious disease in children may be a manifestation of primary immunodeficiency. These genetic disorders represent important experiments of nature with the capacity to elucidate nonredundant mechanisms of human immunity.
Cant, Andrew J +11 more
core +2 more sources
Human inborn errors of immunity: diagnosis and management [PDF]
Exploration of ImmunologyPrimary immunodeficiency disease (PID) now known as inborn errors of immunity (IEI) is genetic disorder(s) that impair the immune system. IEI is a heterogeneous group of diseases of more than 485 lifelong genetic disorders mainly due to intrinsic defect ...
Iftekhar Mahmood
doaj +1 more source
Improvement of Thymopoiesis after Hematopoietic Stem Cell Transplantation by Cytokines: Translational studies in experimental animal models [PDF]
, 2011 Allogeneic hematopoietic stem cell transplantation (AlloHSCT) is a powerful treatment modality that is frequently applied as part of treatment of hematological malignancies, aplastic anemia and inborn errors of hematopoietic progenitor cells.
Wils, E-J. (Evert-Jan)
core +1 more source
Functional genomics in inborn errors of immunity. [PDF]
Immunol RevSummaryInborn errors of immunity (IEI) comprise a diverse spectrum of 485 disorders as recognized by the International Union of Immunological Societies Committee on Inborn Error of Immunity in 2022. While IEI are monogenic by definition, they illuminate various pathways involved in the pathogenesis of polygenic immune dysregulation as in autoimmune or ...
Hurabielle C +3 more
europepmc +4 more sources
Low Baseline Pneumococcal Antibody Titers Predict Specific Antibody Deficiency, Increased Upper Respiratory Infections, and Allergy Sensitization. [PDF]
, 2020 Background:Inadequate titers of pneumococcal antibody (PA) are commonly present among patients with recurrent respiratory infections. Objective:We sought to determine the effect of the degree of inadequacy in baseline PA titers on the subsequent ...
Chernikova, Diana +5 more
core
Immunogenetic profiling to predict risk of invasive fungal diseases : where are we now? [PDF]
, 2011 Invasive fungal diseases remain nowadays life-threatening conditions affecting multiple clinical settings. The onset of these diseases is dependent on numerous factors, of which the "immunocompromised" phenotype of the patients is the more often ...
Aversa, Franco +6 more
core +1 more source
Chimerism and xenotransplantation: New concepts [PDF]
, 1999 In both transplant and infectious circumstances, the immune response is governed by migration and localization of the antigen. If the antigenic epitopes of transgenic xenografts are sufficiently altered to avoid evoking the destructive force of innate ...
Demetris, AJ +5 more
core +1 more source