Results 41 to 50 of about 3,715 (104)
British Journal of Haematology, Volume 207, Issue 2, Page 631-635, August 2025.
Thomas Altmann +11 more
wiley +1 more source
Abstract The spontaneously hypertensive rat (SHR) is a selectively bred animal strain that is frequently used to model attention‐deficit hyperactivity disorder (ADHD) because of certain genetically determined behavioural characteristics. To test the hypothesis that the characteristically altered response to positive reinforcement in SHRs may be due to ...
Yu‐Ting Li +4 more
wiley +1 more source
Using the Hybrid Rat Diversity Panel, we demonstrated that sex and genetic background confer differences in mechanical sensitivity, thermal sensitivity, and oxycodone‐induced analgesia. Created with BioRender.com. Abstract Opioid use disorder (OUD) is an ongoing public health concern in the United States, and relatively little work has addressed how ...
Eamonn P. Duffy +7 more
wiley +1 more source
Drug development advances in human genetics‐based targets
Progress in drug discovery based on targets with favorable LOF variants identified by WES, WGS, and GWAS. Targets primarily include PCSK9, ANGPTL3, HSD17B13, KHK, ASGR1, GPR75, CIDEB, and INHBE. Drug types primarily include small molecules, monoclonal antibodies, RNAi, and CRISPR gene editing therapies.
Xiaoxia Zhang +5 more
wiley +1 more source
The sunflower, an important oilseed crop and food source across the world, is susceptible to several pathogens, which cause severe losses in sunflower production.
Yan Lu +5 more
doaj +1 more source
Para la introducción terapéutica del preparado total de Petiveria alliacea es necesario demostrar la ausencia de efectos dañinos en órganos endocrinos tan importantes como las cápsulas suprarrenales, que intervienen de forma relevante en el mantenimiento
José Mario Parapar de la Riestra +1 more
doaj

