Effects of inbreeding and genetic modification on
Parasites & Vectors, 2010 Background Genetic modification of mosquitoes offers a promising strategy for the prevention and control of mosquito-borne diseases. For such a strategy to be effective, it is critically important that engineered strains are competitive enough to serve ...
Kormaksson Matthias +2 more
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In vivo microscopic voxel-based morphometry with a brain template to characterize strain-specific structures in the mouse brain [PDF]
Scientific Reports, 2017 Hundreds of inbred mouse strains are established for use in a broad spectrum of basic research fields, including genetics, neuroscience, immunology, and cancer.
Keigo Hikishima +5 more
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Whole-genome sequence of the C57L/J mouse inbred strain. [PDF]
G3 (Bethesda), 2014 We sequenced the complete genome of the widely used C57L/J mouse inbred strain. With 40× average coverage, we compared the C57L/J sequence with that of the C57BL/6J and identified many known as well as novel private variants.
Ananda G +3 more
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Inter-strain differences of serotonergic inhibitory pain control in inbred mice [PDF]
, 2010 Background: Descending inhibitory pain control contributes to the endogenous defense against chronic pain and involves noradrenergic and serotonergic systems.
Albuquerque Boris +17 more
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Generating embryonic stem cells from the inbred mouse strain DBA/2J, a model of glaucoma and other complex diseases. [PDF]
PLoS ONE, 2012 Mouse embryonic stem (ES) cells are derived from the inner cell mass of blastocyst stage embryos and are used primarily for the creation of genetically engineered strains through gene targeting.
Laura G Reinholdt +7 more
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Neuropsychopharmacology Reports, 2020 Aims Restraint stress is one of the most widely used experimental methods for generating rodent models of stress‐induced neuropsychiatric disorders, such as depression and anxiety.
Hirotaka Shoji, Tsuyoshi Miyakawa
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Cognitive comorbidities of experimental absence seizures are independent of anxiety
Neurobiology of Disease, 2023 Typical absence seizures (ASs) are brief periods of lack of consciousness, associated with 2.5–4 Hz spike-wave discharges (SWDs) in the EEG, which are highly prevalent in children and teenagers.
Mariana Neuparth-Sottomayor +11 more
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Behavioral profiles of three C57BL/6 substrains
Frontiers in Behavioral Neuroscience, 2010 C57BL/6 inbred strains of mice are widely used in knockout and transgenic research. To evaluate the loss-of-function and gain-of-function effects of the gene of interest, animal behaviors are often examined.
Naoki Matsuo +15 more
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Biomolecules, 2020 Autism spectrum disorders (ASDs) comprise a genetically heterogeneous group of conditions characterized by a multifaceted range of impairments and multifactorial etiology.
Andrea Messina +3 more
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Choosing mates based on the diet of your ancestors: replication of non-genetic assortative mating in Drosophila melanogaster [PDF]
PeerJ, 2015 Assortative mating has been a focus of considerable research because of its potential to influence biodiversity at many scales. Sharon et al. (2010) discovered that an inbred strain of Drosophila melanogaster mated assortatively based on the diet of ...
Michael A. Najarro +3 more
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