A Powerful New Quantitative Genetics Platform, Combining Caenorhabditis elegans High-Throughput Fitness Assays with a Large Collection of Recombinant Strains. [PDF]
, 2015 The genetic variants underlying complex traits are often elusive even in powerful model organisms such as Caenorhabditis elegans with controlled genetic backgrounds and environmental conditions.
Andersen, Erik C +7 more
core +2 more sources
Choosing mates based on the diet of your ancestors: replication of non-genetic assortative mating in Drosophila melanogaster [PDF]
PeerJ, 2015 Assortative mating has been a focus of considerable research because of its potential to influence biodiversity at many scales. Sharon et al. (2010) discovered that an inbred strain of Drosophila melanogaster mated assortatively based on the diet of ...
Michael A. Najarro +3 more
doaj +2 more sources
High-Density Genotypes of Inbred Mouse Strains: Improved Power and Precision of Association Mapping. [PDF]
, 2015 Human genome-wide association studies have identified thousands of loci associated with disease phenotypes. Genome-wide association studies also have become feasible using rodent models and these have some important advantages over human studies ...
Churchill, Gary A +6 more
core +1 more source
Parasites & Vectors, 2010 Background Genetic modification of mosquitoes offers a promising strategy for the prevention and control of mosquito-borne diseases. For such a strategy to be effective, it is critically important that engineered strains are competitive enough to serve ...
Kormaksson Matthias +2 more
doaj +1 more source
Biomolecules, 2020 Autism spectrum disorders (ASDs) comprise a genetically heterogeneous group of conditions characterized by a multifaceted range of impairments and multifactorial etiology.
Andrea Messina +3 more
doaj +1 more source
Maternal immune activation and strain specific interactions in the development of autism-like behaviors in mice. [PDF]
, 2013 It is becoming increasingly apparent that the causes of autism spectrum disorders (ASD) are due to both genetic and environmental factors. Animal studies provide important translational models for elucidating specific genetic or environmental factors ...
Ashwood, P +5 more
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Experimentation with Animals: A Key Aspect of the 3Rs. The Genetic Quality [PDF]
, 2019 The genetic quality of laboratory animals is essential for reproducibility of scientific research. Working with animals of certifiedgenetic quality is still a pending issue in Argentina due to the lack of routine genetic controls, of information on the ...
Castillo, Nadia Sabiela +4 more
core +1 more source
Scientific Reports, 2023 With disease progression, individual differences appear, even in an animal disease model with genetic homogeneity. Therefore, non-invasive long term observation and individual identification is desirable for late-onset diseases.
Hajime Morizumi +2 more
doaj +1 more source
Behavioral profiles of three C57BL/6 substrains
Frontiers in Behavioral Neuroscience, 2010 C57BL/6 inbred strains of mice are widely used in knockout and transgenic research. To evaluate the loss-of-function and gain-of-function effects of the gene of interest, animal behaviors are often examined.
Naoki Matsuo +15 more
doaj +1 more source
Strain-dependent variations in stress coping behavior are mediated by a 5-HT/GABA interaction within the prefrontal corticolimbic system [PDF]
, 2015 Background: Serotonin and γ- Aminobutyric acid (GABA) transmission is crucial in coping strategies. Methods: Here, using mice from 2 inbred strains widely exploited in behavioral neurochemistry, we investigated whether serotonin transmission in medial ...
ANDOLINA, DIEGO +3 more
core +1 more source