Results 31 to 40 of about 2,324,041 (334)

Sperm morphology in two house mouse subspecies: do wild-derived strains and wild mice tell the same story? [PDF]

open access: yesPLoS ONE, 2014
Being subject to intense post-copulatory selection, sperm size is a principal determining component of male fitness. Although previous studies have presented comparative sperm size data at higher taxonomic levels, information on the evolution of sperm ...
Jana Albrechtová   +4 more
doaj   +1 more source

Strain-dependent differences in corticolimbic processing of aversive or rewarding stimuli [PDF]

open access: yes, 2015
Aberrations in the elaboration of both aversive and rewarding stimuli characterize several psychopathologies including anxiety, depression and addiction.
ANDOLINA, DIEGO   +2 more
core   +1 more source

A low coefficient of variation in hepatic triglyceride concentration in an inbred rat strain

open access: yesLipids in Health and Disease, 2020
Background Inbred strains are characterized by less genetic variation, which suggests usefulness of inbred strains for evaluations of various parameters.
Tomoko Shimoda   +8 more
doaj   +1 more source

Establishing a Genetic Detection Protocol of Single Nucleotide Polymorphisms Panels in Inbred Rats Based on Multiplex PCR-LDR

open access: yesShiyan dongwu yu bijiao yixue, 2023
Objective To establish a set of single nucleotide polymorphisms (SNP) detection protocol for inbred rats based on multiplex PCR-ligase detection reaction (LDR).Methods A total of 40 rats SNP sites were selected on chromosomes 1-20 and X of rats among 5 ...
ZHAO Liya   +7 more
doaj   +1 more source

Evidence should trump intuition by preferring inbred strains to outbred stocks in preclinical research.

open access: yesILAR journal, 2014
Inbred strains of mice such as C57BL and BALB/c are more widely used in published work than outbred stocks of mice such as ICR and CD-1. In contrast, outbred stocks of rats such as Wistar and Sprague-Dawley are more widely used than inbred strains such ...
M. Festing
semanticscholar   +1 more source

Genetic factors regulating lung vasculature and immune cell functions associate with resistance to pneumococcal infection [PDF]

open access: yes, 2004
Streptococcus pneumoniae is an important human pathogen responsible for high mortality and morbidity worldwide. The susceptibility to pneumococcal infections is controlled by as yet unknown genetic factors.
Jonczyk, Magda S.   +7 more
core   +5 more sources

Of faeces and sweat. How much a mouse is willing to run: having a hard time measuring spontaneous physical activity in different mouse sub-strains [PDF]

open access: yes, 2017
Physical activity has multiple beneficial effects in the physiology and pathology of the organism. In particular, we and other groups have shown that running counteracts cancer cachexia in both humans and rodents.
Adamo, Sergio   +2 more
core   +3 more sources

Efficient single nucleotide polymorphism discovery in laboratory rat strains using wild rat-derived SNP candidates

open access: yesBMC Genomics, 2005
Background The laboratory rat (Rattus norvegicus) is an important model for studying many aspects of human health and disease. Detailed knowledge on genetic variation between strains is important from a biomedical, particularly pharmacogenetic point of ...
Hedrich Hans J   +5 more
doaj   +1 more source

A phenotypic and molecular characterization of the fmr1-tm1Cgr Fragile X mouse [PDF]

open access: yes, 2004
Fragile X Syndrome is the most common form of\ud inherited mental retardation. It is also known for having\ud a substantial behavioral morbidity, including autistic features. In humans, Fragile X Syndrome is almost always\ud caused by inactivation of the
Bauchwitz, Dr. Robert P.
core   +1 more source

Strain-Dependent Modifier Genes Determine Survival in Zfp423 Mice

open access: yesG3: Genes, Genomes, Genetics, 2020
Zfp423 encodes a transcriptional regulatory protein that interacts with canonical signaling and lineage pathways. Mutations in mouse Zfp423 or its human ortholog ZNF423 are associated with a range of developmental abnormalities reminiscent of ...
Wendy A. Alcaraz   +11 more
doaj   +1 more source

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