Results 11 to 20 of about 5,619,681 (327)

The Effect of Bergenin on Isonicotinic Acid Hydrazide and Rifampicin-Induced Liver Injury Revealed by RNA Sequencing

Molecules, 2023
Bergenin (BER), a natural component of polyphenols, has a variety of pharmacological activities, especially in improving drug metabolism, reducing cholestasis, anti-oxidative stress and inhibiting inflammatory responses.
Ting Li, Chaoyue Yang, Houkang Cao, Siyi Mo, Bo Li, Zhipeng Huang, Ruobing Zhang, Jianzhao Wu, Kefeng Zhang, Ya Gao   +9 more
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AT1R gene rs389566 polymorphism contributes to MACCEs in hypertension patients

BMC Cardiovascular Disorders, 2023
Objective To investigate the possible association between AT1R gene polymorphisms and major adverse cardiovascular and cerebrovascular events (MACCEs) in hypertension patients combined with or without coronary artery disease (CAD) in Xinjiang.
Jun-Yi Luo, Guo-Li Du, Yang-Min Hao, Fen Liu, Tong Zhang, Bin-Bin Fang, Xiao-Mei Li, Xiao-Ming Gao, Yi-Ning Yang   +8 more
doaj   +1 more source

Echinococcus granulosus cyst fluid inhibits KDM6B-mediated demethylation of trimethylated histone H3 lysine 27 and interleukin-1β production in macrophages

Parasites & Vectors, 2023
Background Echinococcus granulosus can manipulate its host's immune response to ensure its own survival. However, the effect of histone modifications on the regulation of the NOD-like receptor protein 3 (NLRP3) inflammasome and downstream interleukin-1β (
Ruolin Lin, Xiaopeng Wang, Caiya Ni, Chunxue Fu, Chun Yang, Dan Dong, Xiangwei Wu, Xueling Chen, Lianghai Wang, Jun Hou   +9 more
doaj   +1 more source

Potential Mechanism of Immune Evasion Associated with the Master Regulator ASCL2 in Microsatellite Stability in Colorectal Cancer

Journal of Immunology Research, 2021
Colorectal cancer (CRC) has two major subtypes, microsatellite instability (MSI) and microsatellite stability (MSS) based on the genomic instability. In this study, using computational programs, we identified 9 master transcription factors (TFs) based on
Qian Yang, Guowei Huang, Liyan Li, Enmin Li, Liyan Xu   +4 more
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EPRS1 correlates with malignant progression in hepatocellular carcinoma

Infectious Agents and Cancer, 2023
Background Glutamyl-prolyl-tRNA synthetase 1 (EPRS1) is an aminoacyl-tRNA synthase involved in the pathology of cancer and other diseases. In this study, we investigated the carcinogenic function, potential mechanism, and clinical significance of EPRS1 ...
Chen Yang, Xiaofeng Yang, Chenghao Liu, Jun Hou, Xueling Chen, Lianghai Wang, Xiangwei Wu   +6 more
doaj   +1 more source

Association of three insulin resistance indices with hypertension and body weight among Uyghur adults in rural areas of Xinjiang, China

The Journal of Clinical Hypertension, 2022
Obesity and insulin resistance are significant contributors to hypertension. There is a high prevalence of obesity among Uyghurs in the rural areas of Xinjiang, China.
YiDan Mao, RuLin Ma, Yu Li, YiZhong Yan, Jia He, DongSheng Rui, Ding YuSong, Xin He, ShengYu Liao, XueYing Sun, ShuXia Guo, Heng Guo   +11 more
doaj   +1 more source

RETRACTED ARTICLE: Upregulation of hsa_circ_0002003 promotes hepatocellular carcinoma progression

BMC Cancer, 2023
Background Circular RNAs (circRNAs), which are involved in various human malignancies, have emerged as promising biomarkers. The present study aimed to investigate unique expression profiles of circRNAs in hepatocellular carcinoma (HCC) and identify ...
Lisha Zhou, Qianwen Wang, Jun Hou, Xiangwei Wu, Lianghai Wang, Xueling Chen   +5 more
doaj   +1 more source

Incidence and Outcomes Associated With Clostridium difficile Infections: A Systematic Review and Meta-analysis [PDF]

, 2020
Importance: An understanding of the incidence and outcomes of Clostridium difficile infection (CDI) in the United States can inform investments in prevention and treatment interventions.
Balkenende, Erin, Blevins, Amy E., Chiang, Hsiu-Yin, Chorazy, Margaret L., Diekema, Daniel J., Herwaldt, Loreen A., Khader, Karim, Kuxhausen, Michelle F., Marra, Alexandre R., McDanel, Jennifer S., Nair, Rajeshwari, Nelson, Richard E., Perencevich, Eli N., Samore, Matthew, Schweizer, Marin L., Ward, Melissa A.   +15 more
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Echinococcus granulosus cyst fluid inhibits inflammatory responses through inducing histone demethylase KDM5B in macrophages

Parasites & Vectors, 2023
Background Echinococcus granulosus cyst fluid (EgCF) weakens macrophage inflammatory responses, thereby enabling the parasite to evade the immune system. However, the role of histone modification in this process remains to be explored. Methods The levels
Xiaopeng Wang, Ruolin Lin, Chunxue Fu, Chun Yang, Dan Dong, Xiangwei Wu, Xueling Chen, Lianghai Wang, Jun Hou   +8 more
doaj   +1 more source

Alterations of RNA splicing patterns in esophagus squamous cell carcinoma

Cell & Bioscience, 2021
Alternative splicing (AS) is an important biological process for regulating the expression of various isoforms from a single gene and thus to promote proteome diversity.
Jiyu Ding, Chunquan Li, Yinwei Cheng, Zepeng Du, Qiuyu Wang, Zhidong Tang, Chao Song, Qiaoxi Xia, Wenjing Bai, Ling Lin, Wei Liu, Liyan Xu, Enmin Li, Bingli Wu   +13 more
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